Email this article IN HIV-INFECTED IMMUNOLOGICAL NON-RESPONDERS, HEPATITIS C VIRUS ERADICATION CONTRIBUTES TO INCOMPLETE NORMALIZATION OF SYSTEMIC INFLAMMATION INDEXES, BUT DOES NOT LEAD TO RAPID CD4+ T-CELL COUNT RECOVERY
- Authors: Saidakova E.V.1, Korolevskaya L.B.1, Shmagel N.G.1, Vlasova V.V.1, Shardina K.Y.1, Chereshnev V.A.1,2, Shmagel K.V.1
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Affiliations:
- Perm Federal Research Center Ural Branch Russian Academy of Sciences
- Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
- Issue: Vol 512, No 1 (2023)
- Pages: 454-459
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/140852
- DOI: https://doi.org/10.31857/S2686738923600243
- EDN: https://elibrary.ru/OYAHSW
- ID: 140852
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Abstract
In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases the systemic inflammation, which interferes with the CD4+ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4+ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called “immunological non-responders” (INRs). HIV-infected patients who received a course of direct-acting antiviral drugs for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected individuals and relatively healthy volunteers. It has been established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4+/CD8+ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete.
About the authors
E. V. Saidakova
Perm Federal Research Center Ural Branch Russian Academy of Sciences
Author for correspondence.
Email: radimira@list.ru
Russian Federation, Perm
L. B. Korolevskaya
Perm Federal Research Center Ural Branch Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, Perm
N. G. Shmagel
Perm Federal Research Center Ural Branch Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, Perm
V. V. Vlasova
Perm Federal Research Center Ural Branch Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, Perm
K. Yu. Shardina
Perm Federal Research Center Ural Branch Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, Perm
V. A. Chereshnev
Perm Federal Research Center Ural Branch Russian Academy of Sciences; Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, Perm; Russian Federation, Yekaterinburg
K. V. Shmagel
Perm Federal Research Center Ural Branch Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, Perm
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