COMBINED GAMMA-RAYS AND CARBON-12 NUCLEI IRRADIATION MODULATES BRAIN CHEMOKINE AND CYTOKINE PRODUCTION AND IMPROVES SPATIAL LEARNING IN TAU P301S, BUT NOT 5xFAD MOUSE LINE

V. S. Kokhan; Кохан В. С.; M. S. Nesterov; Нестеров М. С.; A. I. Levashova; Левашова А. И.

doi:10.31857/S2686738923600139

COMBINED GAMMA-RAYS AND CARBON-12 NUCLEI IRRADIATION MODULATES BRAIN CHEMOKINE AND CYTOKINE PRODUCTION AND IMPROVES SPATIAL LEARNING IN TAU P301S, BUT NOT 5xFAD MOUSE LINE

Authors: Kokhan V.S.¹, Nesterov M.S.², Levashova A.I.²
Affiliations:
1. V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
2. Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia,
Issue: Vol 511, No 1 (2023)
Pages: 349-353
Section: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/135646
DOI: https://doi.org/10.31857/S2686738923600139
EDN: https://elibrary.ru/IZUOEP
ID: 135646

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Abstract
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Abstract

Earlier we showed the pro-cognitive effect of low doses of combined irradiation (including heavy charged particles) on Wistar rats. In the present work we studied the effect of irradiation (gamma-rays, 0.24 Gy; carbon-12, 0.18 Gy, 400 MeV/nucleon) on the course of neurodegenerative process using Tau P301S and 5xFAD transgenic mice lines, experimental models of Alzheimer’s disease. Irradiation led to an increase in pro- and anti-inflammatory cytokines and chemokines (IL-2, IL-6, IL-10, KC) in Tau P301S mice, but not in 5xFAD. At the same time, only the Tau P301S line was found to exhibit radiation-induced improvement in spatial learning.

Keywords

ionizing radiation, carbon-12, neuroinflammation, Alzheimer's disease, spatial learning, interleukins, chemokines

References

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