Email this article COMBINED GAMMA-RAYS AND CARBON-12 NUCLEI IRRADIATION MODULATES BRAIN CHEMOKINE AND CYTOKINE PRODUCTION AND IMPROVES SPATIAL LEARNING IN TAU P301S, BUT NOT 5xFAD MOUSE LINE
- Authors: Kokhan V.S.1, Nesterov M.S.2, Levashova A.I.2
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Affiliations:
- V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
- Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia,
- Issue: Vol 511, No 1 (2023)
- Pages: 349-353
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135646
- DOI: https://doi.org/10.31857/S2686738923600139
- EDN: https://elibrary.ru/IZUOEP
- ID: 135646
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Abstract
Earlier we showed the pro-cognitive effect of low doses of combined irradiation (including heavy charged particles) on Wistar rats. In the present work we studied the effect of irradiation (gamma-rays, 0.24 Gy; carbon-12, 0.18 Gy, 400 MeV/nucleon) on the course of neurodegenerative process using Tau P301S and 5xFAD transgenic mice lines, experimental models of Alzheimer’s disease. Irradiation led to an increase in pro- and anti-inflammatory cytokines and chemokines (IL-2, IL-6, IL-10, KC) in Tau P301S mice, but not in 5xFAD. At the same time, only the Tau P301S line was found to exhibit radiation-induced improvement in spatial learning.
About the authors
V. S. Kokhan
V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
Author for correspondence.
Email: viktor_kohan@hotmail.com
Russian Federation, Moscow
M. S. Nesterov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia,
Email: viktor_kohan@hotmail.com
Russian Federation, Moscow Region, settlement Svetlye Gory
A. I. Levashova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia,
Email: viktor_kohan@hotmail.com
Russian Federation, Moscow Region, settlement Svetlye Gory
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