Email this article D2-LIKE DOPAMINE RECEPTOR DISTRIBUTION IN THE BRAIN OF RATS WITH DIFFERENT TYPES OF GENETIC EPILEPSY
- Authors: Tsyba E.T.1, Birioukova L.M.2, Midzyanovskaya I.S.2, Surina N.M.1, Abbasova K.R.1
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Affiliations:
- Lomonosov Moscow State University, Faculty of Biology
- Institute of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS)
- Issue: Vol 509, No 1 (2023)
- Pages: 161-165
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135640
- DOI: https://doi.org/10.31857/S2686738922700147
- EDN: https://elibrary.ru/NBICLX
- ID: 135640
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Abstract
The study investigated D2-like dopamine receptor (D2DR) binding densities in cortex and striatum between rats with absence and/or audiogenic genetically determined epilepsy and normal Wistar rats by autoradiography. It was shown that D2DR binding density was lower in the dorsal and ventrolateral aspects of nucleus accumbens in epileptic vs non-epileptic rats. Additionally, audiogenic rats had higher motor, somatosensory cortex, and dorsal striatum binding as in contrast with non-audiogenic groups. This data suggests that there is a common neuronal circuit involved in the pathogenesis of generalized epilepsy of both convulsive and non-convulsive forms.
Keywords
About the authors
E. T. Tsyba
Lomonosov Moscow State University, Faculty of Biology
Author for correspondence.
Email: evgeniya.tsyba@mail.ru
Russian, Moscow
L. M. Birioukova
Institute of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS)
Email: evgeniya.tsyba@mail.ru
Russian, Moscow
I. S. Midzyanovskaya
Institute of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS)
Email: evgeniya.tsyba@mail.ru
Russian, Moscow
N. M. Surina
Lomonosov Moscow State University, Faculty of Biology
Email: evgeniya.tsyba@mail.ru
Russian, Moscow
K. R. Abbasova
Lomonosov Moscow State University, Faculty of Biology
Email: evgeniya.tsyba@mail.ru
Russian, Moscow
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