Erythroderma in newborns and infants: differential diagnosis and therapeutic tactics

Erythroderma observed in the first year of a child's life are rare pathological conditions that require special attention from a neonatologist and pediatrician. Neonatal erythroderma can both be a manifestation of physiological and transitional states in newborns, and be a symptom of a number of infectious, metabolic, immune-mediated conditions, some of which have an unfavorable outcome in case of delayed diagnosis. The article presents a clinical observation of a child with neonatal erythroderma, the peculiarities of the course of which determined the need for a differential diagnosis with physiological and transitional states, atopic dermatitis, Leiner-Mousse and Netterton syndromes. Molecular genetic research revealed a mutation in the GJB2 gene, which is responsible for the development of a rare syndromic form of erythroderma described in the structure of Keratitis-Ichtyosis-Deafness syndrome (KID-syndrome). The authors analyzed the features of the clinical picture in correlation with the data of genetic research, and presented possible approaches to therapy. The child's parents agreed to publish the medical history data and display photographs.

children, erythroderma, Netterton's syndrome, KID-syndrome, molecular genetic research, GJB2 gene, ectoderm, connexin