Interferon clinical use: modern view on efficacy and safety. Literature review


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Interferons (IFN) were find about 65 years ago and during this time it was studied structure, types, cells producing this cytokines and genes coding of IFN. It was paid a great attention to IFN functions and biologic role in anti-viral and anti-tumor immunity, and in systemic inflammatory and autoimmune reactions. By biologic effects, which arise in organism by IFN, administrations for IFN clinical use were formed: viral infections and malignancies therapy. Currently, proposed clinical IFN use are scale down, because of not only new (including targeted) drugs, but also increased reports about long-term side effects, caused by IFN. One of the most serious side effects are autoimmune disorders, which make us reconsider IFN therapy to more safety drugs.

作者简介

Timur Valiev

Blokhin National Medical Research Center of Oncology

Email: timurvaliev@mail.ru
д-р мед. наук, зав. детским отд-нием химиотерапии гемобластозов Moscow, Russia

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