Alopecia and celiac disease: A clinical case

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Abstract

Comorbidity is the coexistence of two or more diseases in one patient, interconnected pathogenetically and genetically. Such cases always require an individualized treatment approach. In addition, it can be difficult to find a patient with a similar set of diseases and a positive experience of their treatment to support decisions in challenging cases. The article focuses on two diseases, alopecia and celiac disease, which, coexisting in one child, challenge adequate therapy choice due to the late diagnosis of one of them. The clinical case of a child with alopecia and celiac disease illustrates the issues of comorbidity for the patient and doctors, the mutual impact of the two diseases on the course of the pathological process, and the effectiveness of therapy.

About the authors

Irina N. Kholodova

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: chin5@yandex.ru
ORCID iD: 0000-0003-0090-6980

D. Sci. (Med.)

Russian Federation, Moscow

Yuri V. Vasilyev

Saint Petersburg State Pediatric Medical University

Email: chin5@yandex.ru
ORCID iD: 0000-0001-5102-1774

Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Dmitry I. Kholodov

Children's City Polyclinic No. 94

Email: chin5@yandex.ru

pediatrician

Russian Federation, Moscow

Galina E. Zaydenvarg

Russian Medical Academy of Continuous Professional Education

Email: chin5@yandex.ru

Cand. Sci. (Med.)

Russian Federation, Moscow

References

  1. Оганов Р.Г., Симаненков В.И., Бакулин И.Г., и др. Коморбидная патология в клинической практике. Алгоритмы диагностики и лечения. Клинические рекомендации, 2018. Кардиоваскулярная терапия и профилактика. 2019;18(1): 5-66 [Oganov RG, Simanenkov VI, Bakulin IG. Comorbid pathology in clinical practice. Algorithms for diagnosis and treatment. Clinical guidelines, 2018. Cardiovascular Therapy and Prevention. 2019;18(1):5-66 (in Russian)]. doi: 10.15829/1728-8800-2019-1-5-66
  2. Антонова С.Б., Уфимцева М.А., Бочкарев Ю.М., и др. Выпадение волос (алопеция) у детей: этиология, эпидемиология, особенности клинического течения, дифференциальная диагностика. Педиатрия им. Г.Н. Сперанского. 2020;99(6):148-54 [Antonova SB, Ufimtseva MA, Bochkarev YuM, et al. Hair Loss (Alopecia) in Children: Etiology, Epidemiology, Clinical Features, and Differential Diagnosis. Pediatria n.a. G.N. Speransky. 2020;99(6):148-54 (in Russian)]. doi: 10.24110/0031-403X-2020-99-6-148-154
  3. Messenger AG, McKillop J, Farrant P, et al. British Association of Dermatologists' guidelines for the management of alopecia areata 2012. Br J Dermatol. 2012;166(5):916-26. doi: 10.1111/j.1365-2133.2012.10955.x
  4. Husby S, Koletzko S, Korponay-Szabo IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease. J Pediatr Gastroenterol Nutr. 2012;54(1):136-60. doi: 10.1097/MPG.0b013e31821a23d0
  5. Greco L, Romino R, Coto I, et al. The first large population based twin study of coeliac disease. Gut. 2002;50(5):624-8. doi: 10.1136/gut.50.5.624
  6. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol. 2008;103(1):190-5. doi: 10.1111/j.1572-0241.2007.01471.x
  7. Vermeulen BA, Hogen Esch CE, Yuksel Z, et al. Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect. Scand J Gastroenterol. 2009;44(1):40-5. doi: 10.1080/00365520802116422
  8. Целиакия. Клинические рекомендации. Утверждены Минздравом России, 2020 г. [Celiac Disease. Clinical Guidelines. Approved by the Ministry of Health of the Russian Federation, 2020 (in Russian)].
  9. Дмитриева Ю.А., Тесленко С.Е., Абдурахманова Л.С., и др. Секреты патогенеза целиакии. Практика педиатра. 2024;4:30-6 [Dmitrieva YuA, Teslenko SE, Abdurakhmanova LS, et al. Secrets of the pathogenesis of celiac disease. Pediatrician Practice. 2024;4:30-6 (in Russian)]. EDN:WWXPTS
  10. Гнездная алопеция. Клинические рекомендации. Утверждены Минздравом России, 2024 г. Режим доступа: https://cr.minzdrav.gov.ru/preview-cr/196_2. Ссылка активна на 04.05.2025 [Alopecia Areata. Clinical Guidelines 6. Available at: https://cr.minzdrav.gov.ru/preview-cr/196_2. Accessed: 04.05.2025 (in Russian)].

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