Nutritional therapy for protein-energy malnutrition in children with sepsis

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This review presents meta-analyses on nutrition in patients with critical illness using ASPEN/SCCM (2017), SSC (2012, 2021), ESPNIC (2020), and SSC (2020) pediatric sepsis guidelines. The ESPNIC (2020) guideline, based on new evidence, complements most of the existing ASPEN (2017) guidelines for critical pediatrics. Children’s SSC (2020) did not find direct evidence and sufficient data to develop strong nutritional recommendations for children with sepsis/SS. Many issues remain unresolved, requiring systematic analysis. In the literature search, only a few randomized clinical trials have focused on the assessment and correction of protein-energy malnutrition in pediatric intensive care. Over the past decade, small and large pediatric studies have recommended nutritional therapy. However, given the heterogeneity of children admitted to intensive care units in terms of age, pathology, disease severity, presence of comorbidities, and nutritional status, it is unrealistic to expect that one nutrition strategy applies to all patients requiring intensive care. Therefore, most clinicians emphasize the need for an individualized approach to nutrition support in children, taking into account the pathology, severity, initial nutritional status, and risk–benefit ratio of different nutritional therapies. An extensive search of the literature on the problem did not reveal strong nutritional recommendations for children with sepsis/SS, which dictates the need for future research on the topic and correction of protein-energy malnutrition in children with sepsis/SS.

About the authors

Elmira A. Satvaldieva

Tashkent Pediatric Medical Institute; National Children’s Medical Center

Author for correspondence.
Email: Satvaldieva.el@gmail.com
ORCID iD: 0000-0002-8448-2670
SPIN-code: 9896-8364

MD, Dr. Sci. (Med.), Professor

Uzbekistan, Tashkent; Tashkent

Gulchehra Z. Ashurova

Tashkent Pediatric Medical Institute; National Children’s Medical Center

Email: gulibaur@gmail.com
ORCID iD: 0000-0001-6437-8967
SPIN-code: 7063-0126

MD

Uzbekistan, Tashkent; Tashkent

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