The effect of vitamin D deficiency on cardiovascular risk factors in middle-aged men

according to numerous multicenter studies, 30-40% of the world's population has vitamin D deficiency or insufficiency. The prevalence of vitamin D deficiency is particularly high in countries in northern Europe and northern America due to a lack of ultraviolet radiation. In Russia, 70% of the adult population has 25(OH)D levels below 30 ng/ml, and some studies have reported seasonal variations. The effects of vitamin D deficiency on calcium-phosphorus metabolism and the condition of the musculoskeletal system are well-known and widely reported in the literature. However, there is a lack of research on the effects of vitamin D deficiency on other organs and systems, particularly the cardiovascular system. The available data are often contradictory and unsystematic. This article presents the results of a study conducted by the authors, which demonstrates the impact of vitamin D deficiency and insufficiency on the development of cardiovascular pathology in middle-aged men.

vitamin D, arterial hypertension, endothelial dysfunction, renin-angiotensin system, VDR receptors, prothrombotic factors, HERG/Kv11.1 – channels, СНF