Etiology of periodontitis in the context of glycation of extracellular matrix proteins in periodontal tissues

the relevance of this study is determined by the increasing prevalence of periodontitis and its association with metabolic disorders that modify extracellular matrix proteins. Studying the mechanisms by which protein glycation influences the development of pathological processes in periodontal tissues is of particular importance. The aim of this study is to comprehensively investigate the role of extracellular matrix protein glycation in the pathogenesis of periodontitis and to develop new approaches to the prevention and treatment of this disease. The study established that the extracellular matrix of periodontal tissues is a critical structural component, ensuring the integrity of the periodontal complex. Disruptions in carbohydrate metabolism lead to non-enzymatic glycation of matrix proteins, which disrupts the structural organization of the tissues, reduces the elasticity of connective tissue elements, and impairs reparative processes. It was found that glycated proteins of the extracellular matrix not only undergo structural changes but also become active participants in the pathological process, contributing to the progression of destructive changes. It was established that the interaction between microbial biofilm and components of the modified matrix creates a vicious cycle, in which disruption of carbohydrate metabolism worsens the condition of periodontal tissues.

periodontitis, extracellular matrix, protein glycation, matrix metalloproteinases, periodontal tissues, pathogenesis, metabolic disorders