Etiopathogenetic principles of treatment of acne vulgaris

common acne is one of the most common skin diseases and affects almost the entire population. The mechanism of skin changes in this disease is complex. The anatomical localization of the painful process is the sebaceous glands and the mouths of the hair follicles. During puberty, the sebaceous glands, under the influence of androgenic hormones, begin to produce sebum in large quantities, which gets on the surface of the skin, irritates the ducts of the sebaceous glands and stimulates their excessive keratinization. This leads to a blockage of the hair sac and swelling of the adjacent sebaceous gland. As a result, non-inflammatory, stagnant phenomena occur in the form of open and closed gums. In the sebaceous glands clogged in this way, filled with sebum and deprived of oxygen, favorable conditions are formed for the development of saprophytic bacteria from the Propionibacterium acnes group. These bacteria have the ability to decompose complex lipids to form highly irritating fatty acids, activate complement, and thus are a strong chemotoxic factor for neutrophil granulocytes and cause an inflammatory process. In the case of rupture of the wall of a blocked sebaceous gland due to excessive accumulation of sebum or cosmetic intervention in the area of the comedone, the contents of a small cyst flow into the skin itself, and this leads to an accumulation of neutrophil granulocytes.

etiology, acne, acne, Benzacne gel, acne pathogenesis, Zinerite lotion