Influence of Nanocluster Molybdenum Polyoxometalates on the Morphofunctional State of Fibroblasts in Culture
- Авторы: Ostroushko A.A.1, Ulitko M.V.1,2, Tonkushina M.O.1, Zubarev I.V.1, Medvedeva S.Y.1,3, Danilova I.G.1,3, Gubaeva O.V.1,2, Gagarin I.D.1, Gette I.F.1,3
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Учреждения:
- Yeltsin Ural Federal University
- Institute of Medical Cell Technologies
- Institute of Immunology and Physiology, Ural Branch
- Выпуск: Том 13, № 1-2 (2018)
- Страницы: 1-10
- Раздел: Article
- URL: https://journals.rcsi.science/2635-1676/article/view/220335
- DOI: https://doi.org/10.1134/S199507801801010X
- ID: 220335
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Аннотация
For the culture of normal and transformed fibroblasts, the differential effect of two nanoclusters (Мо72Fe30, Мо132) has been shown. The Мо72Fe30 nanocluster is nontoxic to normal fibroblasts, while the Мо132 cluster shows toxicity to normal and transformed fibroblasts. An analysis of the ultrastructure of the cells under the influence of the nanoclusters has demonstrated the specificity of the changes. The dermal fibroblasts are more resistant to the action of Мо72Fe30; the Мо132 cluster causes extensive disorders in the membrane organelles both in normal and transformed fibroblasts. The results confirm the possibility of applying the Мо72Fe30 nanocluster in biomedicine and the use of the Мо132 nanocluster in oncology.
Об авторах
A. Ostroushko
Yeltsin Ural Federal University
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002
M. Ulitko
Yeltsin Ural Federal University; Institute of Medical Cell Technologies
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002; Yekaterinburg, 620026
M. Tonkushina
Yeltsin Ural Federal University
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002
I. Zubarev
Yeltsin Ural Federal University
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002
S. Medvedeva
Yeltsin Ural Federal University; Institute of Immunology and Physiology, Ural Branch
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002; Yekaterinburg, 620219
I. Danilova
Yeltsin Ural Federal University; Institute of Immunology and Physiology, Ural Branch
Автор, ответственный за переписку.
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002; Yekaterinburg, 620219
O. Gubaeva
Yeltsin Ural Federal University; Institute of Medical Cell Technologies
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002; Yekaterinburg, 620026
I. Gagarin
Yeltsin Ural Federal University
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002
I. Gette
Yeltsin Ural Federal University; Institute of Immunology and Physiology, Ural Branch
Email: ig-danilova@yandex.ru
Россия, Yekaterinburg, 620002; Yekaterinburg, 620219
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