Influence of Nanocluster Molybdenum Polyoxometalates on the Morphofunctional State of Fibroblasts in Culture

Abstract

For the culture of normal and transformed fibroblasts, the differential effect of two nanoclusters (Мо₇₂Fe₃₀, Мо₁₃₂) has been shown. The Мо₇₂Fe₃₀ nanocluster is nontoxic to normal fibroblasts, while the Мо₁₃₂ cluster shows toxicity to normal and transformed fibroblasts. An analysis of the ultrastructure of the cells under the influence of the nanoclusters has demonstrated the specificity of the changes. The dermal fibroblasts are more resistant to the action of Мо₇₂Fe₃₀; the Мо₁₃₂ cluster causes extensive disorders in the membrane organelles both in normal and transformed fibroblasts. The results confirm the possibility of applying the Мо₇₂Fe₃₀ nanocluster in biomedicine and the use of the Мо₁₃₂ nanocluster in oncology.