No 1 (2025)

The average number of years to achieve pregnancy with the birth of a healthy child in couples with infertility remains at the same levels. Currently, a search is underway for new methods that can improve the outcomes of ART programs, but modifiable risk factors such as lifestyle and nutrition remain underestimated. According to the literature, both excess and low body weight have a negative impact on reproductive function, contributing to the development of infertility. Existing recommendations for nutrition and lifestyle correction apply to patients planning natural pregnancy or to patients with concomitant somatic pathology in order to minimize risk factors. A shift in the lipid balance towards relative hyperlipidemia in patients with the onset of clinical pregnancy indicates the fact of the influence of lipid metabolism on the processes of implantation, the onset of pregnancy and full development of the fetus, which emphasizes the influence of lipid metabolism on the outcomes of infertility treatment using ART methods. The aim of the study was to determine the patterns of eating behavior of patients seeking infertility treatment using assisted reproductive technologies. An analysis of the nutritional culture of patients was carried out, nutrition and lifestyle were corrected, followed by an assessment of embryological indicators during a repeat ART program.

The autonomic nervous system (ANS) plays a key role in maintaining homeostasis and adapting the body to stress, especially in the early neonatal period. The sympathetic nervous system (SNS), as the stress-implementing department of the ANS, provides a rapid body response to external and internal stimuli, including painful stimuli. The review presents modern methods for assessing sympathetic activity in newborns. The necessity of developing and improving methods of objective assessment of the sympathetic nervous system in newborns is substantiated in order to prevent and reduce the negative consequences of violations of vital body functions of a newborn child. Special attention is paid to electrodermal activity (EDA). The mechanisms of EDA, its relation to the activities of the SNS, as well as the prospects for using EDA to assess pain, stress response, and monitor the effectiveness of pain relief in neonatal practice are considered.

The study included 88 children aged from 1 to 14 years (Iu = 7.5 years) with dysuric disorders in whom the diagnosis of cystitis was confirmed endoscopically. The main group consisted of 46 children who received the herbal medicinal product Canephron N as monotherapy for acute manifestations of the disease, as well as a preventive measure for 6 months. The control group included 42 children on antibiotic therapy and without preventive measures. The sufficiency of the herbal drug for relieving the symptoms of the disease was noted, as well as a significant decrease in the probability of total relapses (p=0.005), especially exacerbations of cystitis (p=0.041), including those of a recurrent nature (p=0.038). The advantages of Canephron N were also considered based on a comparative assessment of the dynamics of the urine microflora in the acute period and during exacerbations in catamnestic observation. The results obtained indicate the expediency of using Canephron N in children with cystitis for therapeutic and preventive purposes.

To study clinical and anamnestic features of women over 40 years of age with infertility using assisted reproductive with their own oocytes. The study included 520 infertile couples with late reproductive age of the woman (over 40 years) for the period from 2016 to 2024. Descriptive statistics were used to present the clinical and anamnestic characteristics of the group. The causes of infertility were determined and the role of somatic and gynecological diseases in the development of infertility in study cohort were presented. The study of clinical and anamnestic data is a primary task for clinicians, and an individual approach to the correction of concomitant pathology helps improve the outcomes of infertility treatment.

The article discusses the methods of surgical treatment of deep endometriosis and the effect of surgical treatment on fertility. To date, there is no standardized approach to the treatment of deep endometriosis. Due to the variety of symptoms, an individual approach is needed in treatment, which takes into account the nature of the lesion and the patient’sdesires. The choice between first-line surgery and ART is difficult, and doctors must consider various factors, including the patient’sage, severity of symptoms, ovarian reserve, and individual risk factor.