Email this article Modeling of restenosis of main arteries after the intravascular stenting interventions
- Authors: Germanova O.A.1, Germanov V.A.1, Shchukin Y.V.1, Germanov A.V.1, Piskunov M.V.1, Burmistrov A.E.2, Yusupov R.Y.2, Galati G.3
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Affiliations:
- Samara State Medical University
- Samara National Research University
- San Raffaele Hospital
- Issue: Vol 6, No 1 (2021)
- Pages: 45-49
- Section: Cardiology
- URL: https://journals.rcsi.science/2500-1388/article/view/64231
- DOI: https://doi.org/10.35693/2500-1388-2021-6-1-45-49
- ID: 64231
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Abstract
Objectives – to study the mechanism of restenosis after the intra-arterial stenting using the original device for modeling of intra-arterial blood flow.
Material and methods. To perform the experiment, we have created the original device simulating the intra-arterial blood flow. A glass tube of rotameter was the imitation of the arterial vessel. The closed system was filled with the liquid imitating blood, specifically the solution of glycerin the same viscosity as the human blood plasma. Using our original model of intra-artetial blood flow, we were able to study the intra-arterial hemodynamics under different conditions of cardiovascular system functioning, including arrhythmias.
Results. In extrasystolic arrhythmia, during the spread of the first post-extrasystolic wave, we observed the intensive impact of pressure wave (the indicator was the silk thread) on the vessel walls with forming of reflected and standing waves. Putting the piezo crystal probe of pressure inside the tube, we verified our observations. The increase of pressure during the spread of the first post-extrasystolic wave in multiple measurements had a mean value of 160% in comparison with the pressure during the regular heart rhythm.
Conclusion. The hydraulic shock appears during the spread of the first post-extrasystolic wave in the arterial vessel. Its effect on hemodynamics grows in case of the frequent extrasystoles and allorhythmia. The mechanical impact of hydraulic shock in extrasystoles can be the starting point of the restenosis onset and progressing in the intra-arterial stent.
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##article.viewOnOriginalSite##About the authors
Olga A. Germanova
Samara State Medical University
Author for correspondence.
Email: olga_germ@mail.ru
ORCID iD: 0000-0003-4833-4563
PhD, Organ function test doctor, Functional Diagnostics department
Russian Federation, SamaraVladimir A. Germanov
Samara State Medical University
Email: rean1mator2323@gmail.com
ORCID iD: 0000-0003-4239-5066
PhD, X-ray-endovascular diagnostics and treatment doctor, Faculty surgery clinic, Clinics of SamSMU
Russian Federation, SamaraYurii V. Shchukin
Samara State Medical University
Email: samgmu_pt@mail.ru
ORCID iD: 0000-0003-0387-8356
PhD, Professor, Head of the Chair of Introduction to internal diseases
Russian Federation, SamaraAndrei V. Germanov
Samara State Medical University
Email: a.v.germanov@samsmu.ru
ORCID iD: 0000-0002-0367-7776
PhD, Associate professor, Chair of Introduction to internal diseases
Russian Federation, SamaraMaksim V. Piskunov
Samara State Medical University
Email: maksim.piskunov@list.ru
PhD, Associate professor, Chair of Introduction to internal diseases, Head of Cardiology department, Clinics of SamSMU.
Russian Federation, SamaraAndrei E. Burmistrov
Samara National Research University
Email: barishnikov_a@mail.ru
laboratory engineer
Russian Federation, SamaraRinat Yu. Yusupov
Samara National Research University
Email: vikaprokhorenko@gmail.com
ORCID iD: 0000-0001-5472-4555
laboratory engineer
Russian Federation, SamaraGiuseppe Galati
San Raffaele Hospital
Email: giuseppe.galati5@gmail.com
ORCID iD: 0000-0002-8001-1249
cardiologist Italy, Milan
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