Email this article Prognosis of the combination therapy results in patients with synchronous metastases of colorectal cancer
- Authors: Kozlov S.V.1, Kaganov O.I.1, Moryatov A.A.1, Kozlov A.M.2, Borisov A.P.1
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Affiliations:
- Samara State Medical University
- Samara Regional Clinical Oncology Dispensary
- Issue: Vol 4, No 3 (2019)
- Pages: 60-64
- Section: Oncology
- URL: https://journals.rcsi.science/2500-1388/article/view/43788
- DOI: https://doi.org/10.35693/2500-1388-2019-4-3-60-64
- ID: 43788
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Abstract
Objectives – to optimize the indications for radiofrequency thermal ablation in patients with synchronous multiple metastases of colorectal cancer to the liver on the basis of prognostic treatment results.
Material and methods. The study group included 78 patients with colorectal cancer with synchronous multiple bilobar liver metastases, who have underwent combined treatment in the period of 2007– 2015, such as cytoreductive surgery removing the primary intestinal tumor in combination with RFA of metastases in the liver, followed by chemotherapy.
Results. A computer program for preoperative risk assessment of disease progression was developed and introduced in clinical practice. It is based on the results of the analysis of the factors, predicting the risk of relapse during the first year after cytoreductive surgery with RFA of synchronous multiple CRC liver metastases.
Conclusion. The index of metastatic liver damage (the product of the sum of the diameters of metastatic liver lesions by their number), the mutational status of the KRAS gene, CEA values are significant factors in predicting the progression of the disease, which can optimize indications for radiofrequency thermal ablation in the treatment of patients with stage IV CRC with synchronous metastases to the liver.
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##article.viewOnOriginalSite##About the authors
Sergey V. Kozlov
Samara State Medical University
Email: amihalu4@gmail.com
PhD, Professor, Head of the Department of oncology
Russian Federation, SamaraOleg I. Kaganov
Samara State Medical University
Email: amihalu4@gmail.com
ORCID iD: 0000-0002-4569-1031
Scopus Author ID: 57196466538
PhD, Professor, Department of oncology
Russian Federation, SamaraAleksandr A. Moryatov
Samara State Medical University
Email: amihalu4@gmail.com
PhD, Associate Professor, Department of oncology
Russian Federation, SamaraAleksey M. Kozlov
Samara Regional Clinical Oncology Dispensary
Author for correspondence.
Email: amihalu4@gmail.com
PhD, physician, Department of abdominal oncology
Russian Federation, SamaraAleksandr P. Borisov
Samara State Medical University
Email: amihalu4@gmail.com
PhD, Associate Professor of Department of oncology
Russian Federation, SamaraReferences
- Zaridze DG, Kaprin AD, Stilidi IS. Dynamics of morbidity and mortality from malignant neoplasms in Russia. Oncology issues. 2018;5:578–591. (In Russ.) [Заридзе Д.Г., Каприн А.Д., Стилиди И.С. Динамика заболеваемости и смертности от злокачественных новообразований в России. Вопросы онкологии. 2018;5:578–591].
- Abdalla EK, Bauer TW, Chun YuS, D’Angelica M, et al. Locoregional surgical and interventional therapies for advanced colorectal cancer liver metastases: expert consensus statements. HPB (Oxford). 2013;15(2):119–130. doi: 10.1111/j.1477-2574.2012.00597.x
- Skipenko OG, Petrenko KN, Bagmet NN, et al. Radiofrequency ablation in the combined treatment of metastatic colorectal liver cancer. Surgery. Magazine them. N.I. Pirogov. 2016;12:4–18. (In Russ.) [Скипенко О.Г., Петренко К.Н., Багмет Н.Н. и др. Радиочастотная абляция в комбинированном лечении метастатического колоректального рака печени. Хирургия. Журнал им. Н.И. Пирогова. 2016;(12):4–18]. doi: 10.17116/hirurgia 2016124-18
- Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E35986. doi: 10.1002/ijc.29210
- Yang DJ, Luo KL, Liu H, et al. Metaanalysis of transcatheter arterial chemoembolization plus radiofrequency ablation versus transcatheter arterial chemoembolization alone for hepatocellular carcinoma. Oncotarget. 2017;8(2):2960–70. doi: 10.18632/oncotarget.13813
- Yamakado K, Inaba Y, Sato Y, et al. Radiofrequency ablation combined with hepatic arterial chemoembolization using degradable starch microsphere mixed with mitomycin C for the treatment of liver metastasis from colorectal cancer: a prospective multicenter study. Cardiovasc interventi radiol. 2017;40(4):560–567.
- Sidorov DV, Lozhkin MV, Petrov LO, et al. Methods for assessing the functional status of the liver in the planning of anatomical resections for primary and metastatic tumors: current status of the problem, own experience and prospects. Research and practice in medicine. 2015;2(1):13–20. (In Russ.) [Сидоров Д.В., Ложкин М.В., Пет-ров Л.О. и др. Методы оценки функционального статуса печени при планировании анатомических резекций по поводу первичных и метастатических опухолей: современное состояние проблемы, собственный опыт и перспективы. Исследования и практика в медицине. 2015;2(1):13–20].
- Sidorov DV, Bolotina LV, Lozhkin MV, et al. The first experience of a two-stage in situ split liver resection in a patient with bilobar metastases of colorectal cancer during perioperative chemotherapy. Annals of surgical hepatology. 2014;3:107–112. (In Russ.) [Сидоров Д.В., Болотина Л.В., Ложкин М.В. и др. Первый опыт двухэтапной резекции печени по типу "in situ split" у пациентки с билобарными метастазами колоректального рака на фоне периоперационной полихимиотерапии. Анналы хирургической гепатологии. 2014;3:107–112].
- Ananiev VS, Artamonova EV, Achkasov SI, et al. Clinical recommendations for the diagnosis and treatment of patients with colon cancer. Association of Oncologists of Russia. M., 2014. (In Russ.) [Ананьев В.С., Артамонова Е.В., Ачкасов С.И. и др. Клинические рекомендации по диагностике и лечению больных раком ободочной кишки. Ассоциация онкологов России. М., 2014].
- Stang A, Fischbach R, Teichmann W, et al. A systematic review on the clinical benefit and role of radiofrequency ablation as treatment of colorectal liver metastases. Eur J Cancer. 2009;45(10):1748–1756. doi: 10.1016/j.ejca.2009.03.012
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