MODERN ASPECTS OF THE ETIOLOGY AND PATHOGENESIS OF UTERINE FIBROID TUMORS

Uterine myoma is a benign, hormone-sensitive proliferating tissue. It is one of the most common tumors of women's reproductive system in most countries of the world, and it is often the main cause of hysterectomies, especially among fertile females, determining the social significance of this disease. Domestic and foreign researches are continuing to look for the reasons of this worldwide problem. The article describes the present view on the etiology, pathogenesis and morphogenesis of uterine fibroids. It presents the data on the role of steroid hormones and their receptors, processes of neoangiogenesis, their stimulants and inhibitors (VERGF, EGF, IGF-1, TGF, PDGF, MMPs), proliferation and apoptosis disorders (protooncogene Bcl-2, nuclear phosphoprotein p53). The influence of gene mutations, molecular-genetic markers, as well as immune system mechanisms on tumor growth and development were studied.

uterine fibroid tumors, steroid hormones, neoangiogenesis, growth factors, proliferation, apoptosis, gene mutations