The importance of new therapeutic targets for neutrophil inflammation regulation in case of broncho-obstructive pulmonary diseases

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Search for effective therapeutic targets to control neutrophilic inflammation in chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) is an urgent task of the research.

The aim: to evaluate the importance of P-selectin and siglec-9 in regulation of neutrophilic inflammation taking place in broncho-obstructive pulmonary diseases.

Material and methods. A study of patients suffering from broncho-obstructive diseases was made in 3 groups: group I – patients with BA of mixed genesis (n = 44), group II – patients with COPD (n = 36), control group (n = 30). Clinical, spirometric parameters and immunological markers were assessed using enzyme immunoassay (P-selectin, siglec-9, interleukins 4 and 8, tumor necrosis factor-alpha, interferon gamma).

Results. Median values of P-selectin in case of mixed BA and COPD were at the level of 60.48 (41.48– 147.17) and 91.17 (53.72–135.60) pg/ml, respectively, that had statistically significant differences from the control group, where this index was 47.67 (40.34–65.98) pg/ml. The level of P-selectin in BA and COPD groups did not differ significantly. Siglec-9 value was very low in all groups, but 15 patients were positive for this marker. Mainly they were patients with mixed BA (n = 11). Multivariate cluster analysis, including the main phenotypic signs of diseases (age, smoking status, body mass index) and levels of P-selectin, Siglec-9, interleukin 4, tumor necrosis factor-alpha, interferon gamma, showed that the most consistent features for clustering were smoking, age, body mass index, concentrations of P-selectin, interferon gamma and interleukin 4.

Conclusion. The role of P-selectin and siglec-9 in neutrophilic inflammation regulation in patients with chronic broncho-obstructive pulmonary diseases was ambiguously estimated in the current study. In our opinion, the most convincing promising therapeutic target for controlling neutrophilic inflammation may be P-selectin.

作者简介

Vitaly Kupaev

Samara State Medical University of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: vk1964sam@rambler.ru
ORCID iD: 0000-0003-2639-0003

MD, Dr. Sci. (Medicine), professor, head of the Department of family medicine with a course of telemedicine technologies

俄罗斯联邦, Samara

Alexander Shagurov

Samara State Medical University of the Ministry of Healthcare of Russia

Email: ashagurov@yandex.ru
ORCID iD: 0000-0001-6508-3095

MD, postgraduate student of the Department of family medicine with a course in telemedicine technologies

俄罗斯联邦, Samara

Larisa Limareva

Samara State Medical University of the Ministry of Healthcare of Russia

Email: l.v.limareva@samsmu.ru
ORCID iD: 0000-0003-4529-5896

MD, Dr. Sci. (Biology), associate professor, professor of the Department of general and clinical microbiology, immunology and allergology

俄罗斯联邦, Samara

Ksenia Tkachenko

V.D. Seredavin Samara Regional Clinical Hospital

Email: Ksenya2009@list.ru
ORCID iD: 0009-0006-7433-6609

MD, pulmonologist 

俄罗斯联邦, Samara

Anna Kuritsyna

Samara State Medical University of the Ministry of Healthcare of Russia

Email: a.p.kuricyna@samsmu.ru
ORCID iD: 0000-0003-2799-7632

MD, specialist at the Department of human metagenomics of Scientific and Educational Professional Center for Genetic and Laboratory Technologies

俄罗斯联邦, Samara

参考

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2. Fig 1. Median P-selectin (SELP) value in the comparison groups

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3. Fig. 2. Cluster analysis of the studied patients with chronic obstructive pulmonary disease and bronchial asthma

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