The importance of new therapeutic targets for neutrophil inflammation regulation in case of broncho-obstructive pulmonary diseases
- Autores: Kupaev V.1, Shagurov A.1, Limareva L.1, Tkachenko K.2, Kuritsyna A.1
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Afiliações:
- Samara State Medical University of the Ministry of Healthcare of Russia
- V.D. Seredavin Samara Regional Clinical Hospital
- Edição: Volume 10, Nº 6 (2024)
- Páginas: 15-22
- Seção: ORIGINAL STUDIES
- URL: https://journals.rcsi.science/2412-4036/article/view/264890
- DOI: https://doi.org/10.18565/therapy.2024.6.15-22
- ID: 264890
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Resumo
Search for effective therapeutic targets to control neutrophilic inflammation in chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) is an urgent task of the research.
The aim: to evaluate the importance of P-selectin and siglec-9 in regulation of neutrophilic inflammation taking place in broncho-obstructive pulmonary diseases.
Material and methods. A study of patients suffering from broncho-obstructive diseases was made in 3 groups: group I – patients with BA of mixed genesis (n = 44), group II – patients with COPD (n = 36), control group (n = 30). Clinical, spirometric parameters and immunological markers were assessed using enzyme immunoassay (P-selectin, siglec-9, interleukins 4 and 8, tumor necrosis factor-alpha, interferon gamma).
Results. Median values of P-selectin in case of mixed BA and COPD were at the level of 60.48 (41.48– 147.17) and 91.17 (53.72–135.60) pg/ml, respectively, that had statistically significant differences from the control group, where this index was 47.67 (40.34–65.98) pg/ml. The level of P-selectin in BA and COPD groups did not differ significantly. Siglec-9 value was very low in all groups, but 15 patients were positive for this marker. Mainly they were patients with mixed BA (n = 11). Multivariate cluster analysis, including the main phenotypic signs of diseases (age, smoking status, body mass index) and levels of P-selectin, Siglec-9, interleukin 4, tumor necrosis factor-alpha, interferon gamma, showed that the most consistent features for clustering were smoking, age, body mass index, concentrations of P-selectin, interferon gamma and interleukin 4.
Conclusion. The role of P-selectin and siglec-9 in neutrophilic inflammation regulation in patients with chronic broncho-obstructive pulmonary diseases was ambiguously estimated in the current study. In our opinion, the most convincing promising therapeutic target for controlling neutrophilic inflammation may be P-selectin.
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##article.viewOnOriginalSite##Sobre autores
Vitaly Kupaev
Samara State Medical University of the Ministry of Healthcare of Russia
Autor responsável pela correspondência
Email: vk1964sam@rambler.ru
ORCID ID: 0000-0003-2639-0003
MD, Dr. Sci. (Medicine), professor, head of the Department of family medicine with a course of telemedicine technologies
Rússia, SamaraAlexander Shagurov
Samara State Medical University of the Ministry of Healthcare of Russia
Email: ashagurov@yandex.ru
ORCID ID: 0000-0001-6508-3095
MD, postgraduate student of the Department of family medicine with a course in telemedicine technologies
Rússia, SamaraLarisa Limareva
Samara State Medical University of the Ministry of Healthcare of Russia
Email: l.v.limareva@samsmu.ru
ORCID ID: 0000-0003-4529-5896
MD, Dr. Sci. (Biology), associate professor, professor of the Department of general and clinical microbiology, immunology and allergology
Rússia, SamaraKsenia Tkachenko
V.D. Seredavin Samara Regional Clinical Hospital
Email: Ksenya2009@list.ru
ORCID ID: 0009-0006-7433-6609
MD, pulmonologist
Rússia, SamaraAnna Kuritsyna
Samara State Medical University of the Ministry of Healthcare of Russia
Email: a.p.kuricyna@samsmu.ru
ORCID ID: 0000-0003-2799-7632
MD, specialist at the Department of human metagenomics of Scientific and Educational Professional Center for Genetic and Laboratory Technologies
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