Use of erenumab in real clinical practice
- Authors: Berdnikova A.V.1,2, Kadymova N.B.1, Latysheva N.V.1,2, Naprienko M.V.1,2, Filatova E.G.1,2
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Affiliations:
- Academician A. Vein Clinic of Headache and Autonomic Disturbances
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
- Issue: Vol 10, No 3 (2024)
- Pages: 164-174
- Section: ACTUAL ISSUES OF PHARMACOTHERAPY AND PREVENTIVE TREATMENT
- URL: https://journals.rcsi.science/2412-4036/article/view/259259
- DOI: https://doi.org/10.18565/therapy.2024.3.164-174
- ID: 259259
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Abstract
Migraine is a primary headache (PH), and it is the one of the leading causes of disability in the world. Currently, a division into episodic and chronic migraine is accepted, however, the boundary between these forms is arbitrary, and the presence of one or more comorbid diseases in a patient increases the risk of chronic episodic migraine and may reduce the efficacy of therapy. Tablet medications approved for the preventive treatment of migraine are nonspecific, poorly tolerated, and patient adherence to such kind of treatment is extremely low. Monoclonal antibodies to calcitonin gene-related peptide (CGRP) or its receptor (anti-CGRP mAb) have become the first targeted preventive therapy for migraine.
The aim: to determine the efficacy and safety of anti-CGRP mAb of erenumab in real clinical practice in patients with episodic and chronic migraine.
Material and methods. 76 patients diagnosed with diagnoses chronic and episodic migraine were included in the study according to the criteria of the International classification of headache disorders, 3rd revision. During 3 months all the participants were given erenumab 70 mg subcutaneously for every month. From the beginning and every month, a clinical interview, estimation of the headache diary, and completion of questionnaires for anxiety, depression, impact of headache on the quality of life, and sleep quality assessment were performed.
Results. In patients with both chronic and episodic migraine after 1 and 3 months of erenumab therapy, there was a significant reduction in the frequency of headaches in general, migraine headaches, days with analgesics, as well as positive changes in questionnaire data. Treatment-arising adverse events were of low prevalence.
Conclusion. Erenumab is an effective and safe drug when used in real clinical practice in patients with both episodic and chronic migraine, including multimorbid patients.
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##article.viewOnOriginalSite##About the authors
Anna V. Berdnikova
Academician A. Vein Clinic of Headache and Autonomic Disturbances; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Author for correspondence.
Email: asimcin@mail.ru
ORCID iD: 0000-0002-4447-2152
MD, assistant at the Department of nervous diseases of Institute of Professional Education; neurologist
Russian Federation, Moscow; MoscowNatalia B. Kadymova
Academician A. Vein Clinic of Headache and Autonomic Disturbances
Email: natagubanova@mail.ru
ORCID iD: 0009-0005-8965-9980
MD, PhD (Medicine), neurologist
Russian Federation, MoscowNina V. Latysheva
Academician A. Vein Clinic of Headache and Autonomic Disturbances; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: ninalat@gmail.com
ORCID iD: 0000-0001-9600-5540
MD, Dr. Sci. (Medicine), associate professor, professor of the Department of nervous diseases of Institute of Professional Education; neurologist
Russian Federation, Moscow; MoscowMargarita V. Naprienko
Academician A. Vein Clinic of Headache and Autonomic Disturbances; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: mv_naprienko@mail.ru
ORCID iD: 0000-0003-4204-2279
MD, Dr. Sci. (Medicine), associate professor, professor of the Department of sports medicine and medical rehabilitation of N.V. Sklifosovsky Institute of Clinical Medicine; neurologist
Russian Federation, Moscow; MoscowElena G. Filatova
Academician A. Vein Clinic of Headache and Autonomic Disturbances; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: eg-filatova@mail.ru
ORCID iD: 0000-0001-9978-4180
MD, Dr. Sci. (Medicine), professor, professor of the Department of nervous diseases of Institute of Professional Education; neurologist
Russian Federation, Moscow; MoscowReferences
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