Still’s disease is a great mimic of systemic inflammatory response syndrome?
- Authors: Melnikova L.V.1, Lokhina T.V.2, Berenshtein N.V.2, Timofeeva N.A.3
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Affiliations:
- Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
- Penza Institute for Further Training of Physicians – branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
- G.A. Zakharyin Clinical Hospital No. 6
- Issue: Vol 9, No 2 (2023)
- Pages: 80–84
- Section: CLINICAL CASE
- URL: https://journals.rcsi.science/2412-4036/article/view/258851
- DOI: https://doi.org/10.18565/therapy.2023.2.80–84
- ID: 258851
Cite item
Abstract
Still’s disease in adults (ADS) is a rare systemic autoinflammatory disease. Fever, arthralgia, rash, and neutrophilic leukocytosis are dominating in its clinical picture. These indexes let doctors to suspect infectious diseases, sepsis and prescribe antibiotic therapy, which is ineffective. Article presents a case of a disease that debuted with high fever, shortness of breath, severe weakness and myalgia. Female patient was diagnosed according to the present symptoms, laboratory signs, taking into account the criteria of Yamaguchi M. et al. and by excluding infectious and autoimmune diseases, malignant neoplasms. Treatment with corticosteroids resulted in complete clinical remission.
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##article.viewOnOriginalSite##About the authors
Lyudmila V. Melnikova
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Author for correspondence.
Email: lumel2408@yandex.ru
ORCID iD: 0000-0003-4688-1272
MD, associate professor, professor the Department of general medical practice and polyclinic therapy, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Russian Federation, 125445, Moscow,19/38 Belomorskaya StrTatyana V. Lokhina
Penza Institute for Further Training of Physicians – branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Email: ltv-13@mail.ru
ORCID iD: 0000-0002-9493-444X
MD, head of the Department of therapy, cardiology, functional diagnostics and rheumatology, Penza Institute for Further Training of Physicians – branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Russian Federation, 440060, Penza,8A Stasova Str.Natalya V. Berenshtein
Penza Institute for Further Training of Physicians – branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Email: berenshtein2011@yandex.ru
ORCID iD: 0000-0002-1589-2799
PhD in Medical Sciences, associate professor of the Department of ultrasound diagnostics, Penza Institute for Further Training of Physicians – branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Russian Federation, 440060, Penza,8A Stasova Str.Natalya A. Timofeeva
G.A. Zakharyin Clinical Hospital No. 6
Email: nataliatimofeeva1805@gmail.com
deputy chief physician for medicine of G.A. Zakharyin Clinical Hospital No. 6
Russian Federation, 440071, Penza,7 Stasova Str.References
- Betrains A., Staels F., Schrijvers R. et al. Systemic autoinflammatory disease in adults. Autoimmun Rev. 2021; 20(4): 102774. https://dx.doi.org/10.1016/j.autrev.2021.102774.
- Насонов Е.Л., Файст Е. Болезнь Стилла взрослых: новые горизонты. Научно-практическая ревматология. 2021; 59(6): 645–665. [Nasonov E.L., Feist E. Adult Still’s disease: New horizons. Nauchno-prakticheskaya revmatologiya = Scientific and practical rheumatology. 2021; 59(6): 645–665 (In Russ.)]. https://dx.doi.org/10.47360/1995-4484-2021-643-663. EDN: LFHDGL.
- Моисеев С.В., Рамеев В.В. Дифференциальный диагноз системных аутовоспалительных заболеваний. Клиническая фармакология и терапия. 2022; 31(2): 5–13. [Moiseev S.V., Rameev V.V. Differential diagnosis of systemic autoinflammatory diseases. Klinicheskaya farmakologiya i terapiya = Clinical pharmacology and therapy. 2022; 31(2): 5–13 (In Russ.)]. https://dx.doi.org/10.32756/0869-5490-2022-2-5-13. EDN: UHSKNW.
- Feist E., Mitrovic S., Fautrel B. Mechanisms, biomarkers and targets for adult-onset Still΄s disease. Nat Rev Rheumatol. 2018; 14(10): 603–18. https://dx.doi.org/10.1038/s41584-018-0081-x.
- Efthimiou P., Kontzias A., Hur P. et al. Adult-onset Still’s disease in focus: Clinical manifestations, diagnosis, treatment, and unmet needs in the era of targeted therapies. Semin Arthritis Rheum. 2021; 51(4): 858–74. https://dx.doi.org/10.1016/j.semarthrit.2021.06.004.
- Chen P.D., Yu S.L., Chen S., Weng X.L. Retrospective study of 61 patients with adult-onset Still’s disease admitted with fever of unknown origin in China. Clin Rheumatol. 2012; 31(1): 175–81. https://dx.doi.org/10.1007/s10067-011-1798-y.
- Franchini S., Dagna L., Salvo F. et al. Adult onset Still’s disease: Clinical presentation in a large cohort of Italian patients. Clin Exp Rheumatol. 2010; 28(1): 41–48.
- Клинические рекомендации (проект). Сепсис (у взрослых). Ассоциация анестезиологов-реаниматологов, Российский Сепсис-форум, Российское общество хирургов, Российская Ассоциация специалистов по лечению хирургических инфекций, Межрегиональная Ассоциация по клинической микробиологии и антимикробной химиотерапии, Альянс клинических химиотерапевтов и микробиологов, Общероссийская общественная организация специалистов в сфере медицины катастроф, Российское общество скорой медицинской помощи. Доступ: http://общество-хирургов.рф/publikaci/proekt-nkr-po-sepsisu-u-vzroslyh.html (дата обращения – 01.03.2023). [Clinical guidelines (project). Sepsis (in adults). Association of Anesthesiologists-Resuscitators, Russian Sepsis-Forum, Russian Society of Surgeons, Russian Association of Specialists in the Treatment of Surgical Infections, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy, Alliance of Clinical Chemotherapists and Microbiologists, All-Russian Public Organization of Specialists in Disaster Medicine, Russian Society for Emergency Medicine Help. URL: http://общество-хирургов.рф/publikaci/proekt-nkr-po-sepsisu-u-vzroslyh.html (date of access – 01.03.2023) (In Russ.)].
- Yamaguchi M., Ohta A., Tsunematsu T. et al. Preliminary criteria for classification of adult Still΄s disease. J Rheumatol. 1992; 19(3): 424–30.
- Fautrel B., Zing E., Golmard J.L. et al. Proposal for a new set of classification criteria for adult-onset Still disease. Medicine (Baltimore). 2002; 81(3): 194–200. https://dx.doi.org/10.1097/00005792-200205000-00003.