用利多卡因稀释的头孢曲松的肌肉注射作为死因的问题（病例）

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在临床和专家实践中，有利多卡因肌肉注射后的病理过程的案例，其形式是毒性反应和过敏性休克，但是关于儿童死亡率的信息不多并不齐全。所发现的形态特征被认为是非特异性的，这导致很难解释研究结果和确定死亡原因。

我们研究了用百分之二的利多卡因稀释的头孢曲松的肌肉注射作为2岁儿童死因的案例。引用了一具尸体的初步检查和委托检查的结果，包括重复病理组织学检查的数据。对用百分之二的利多卡因稀释的头孢曲松的肌肉注射作为死因（包括毒性作用（过量）或过敏性休克的发展）的专家结论的客观化来说，需要评估临床症状的顺序及其性质，考虑到给药的途径，进行完整的病理组织学和形态学的检查，以及进行强制性的法医化学检查来测定这些药物在内脏器官和血液中的浓度。

一系列病理形态研究的数据，包括过敏性休克靶器官的变化和明显的血液循环障碍，可以被认为是过敏反应的验证性形态学标志。

我们认为需要对研究问题进行深入研究，以及使现有信息系统化。

作者简介

Elena N. Travenko

Kuban State Medical University

Email: elenaschon@yandex.ru
ORCID iD: 0000-0001-7403-2521
SPIN 代码: 8748-3506

MD, Dr. Sci. (Med.), Assistant Professor

俄罗斯联邦, Krasnodar

Valeriy A. Porodenko

Kuban State Medical University

Email: porodenko52@mail.ru
ORCID iD: 0000-0001-6353-7380
SPIN 代码: 6685-8824

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Krasnodar

Anastasia V. Surikova

Kuban State Medical University

编辑信件的主要联系方式.
Email: avsurikova56@yandex.ru
ORCID iD: 0000-0003-4883-0815
俄罗斯联邦, Krasnodar

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2. Fig. 1. Lymphoid infiltration with eosinophilic leukocytes in the tracheal wall. Coloring: hematoxylin and eosin, ×20.

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3. Fig. 2. Accumulation of eosinophilic leukocytes in the lumens of the vessels of the lungs. Coloring: hematoxylin and eosin, ×100.

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4. Fig. 3. Minor polymorphic cell infiltration and eosinophilic leukocytes in the bronchial wall. Coloring: hematoxylin and eosin, ×100.

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5. Fig. 4. Spasm of bronchioles. Coloring: hematoxylin and eosin, ×20.

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6. Fig. 5. The presence of homogeneous brown masses in the lumen of the bronchioles, with an admixture of cells of desquamated brochiolar epithelium. Coloring: hematoxylin and eosin, ×20.

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7. Fig. 6. Hemodynamic disturbances in the microvasculature system: mixing of formed elements from plasma, with an admixture of eosinophilic leukocytes. Coloring: hematoxylin and eosin, ×20.

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