Work experience bureau of forensic medicine of Moscow region in the context of a pandemic caused by a new coronavirus infection

Cover Page

Cite item

Full Text

Abstract

Background: The article presents the results of studying cases of deaths of individuals from a new coronavirus infection according to forensic research.

Aims: The aim of the study was to generalize and identify patterns of damage to internal organs and body systems in cases of death caused by COVID-19 without medical assistance based on the study results of forensic research of corpses.

Results: A total of 198 cases of fatal outcomes from a new coronavirus infection was studied. The frequency of fatal outcomes was determined in various age groups. The leading morphological manifestations of internal organ lesions were established. Absolute (abs) and relative (%) frequencies were calculated for qualitative variables. The lungs were found to be most susceptible to changes. In 77.8% of cases, pathological changes corresponded to the acute phase of diffuse alveolar damage. In addition to lung damage, the most common sign was the depletion of spleen parenchyma by lymphocytes, indicating an immune inflammatory response of the body.

Conclusion: The identified characteristic morphological signs of alveolar lung damage in COVID-19 can be used as a differential diagnosis of lung damage from shocks of other etiology.

About the authors

Andrey N. Prikhodko

State Institution of Health, Moscow region «Bureau of Forensic Medical Examination»

Email: prihodko@sudmedmo.ru
ORCID iD: 0000-0001-6788-2907

Head of Bureau of Forensic Medical Expertise of Moscow Region

Russian Federation, Moscow

Aleksandr V. Maksimov

State Institution of Health, Moscow region «Bureau of Forensic Medical Examination»; M.F. Vladimirsky Moscow Regional Research Clinical Institute

Author for correspondence.
Email: maksimov@sudmedmo.ru
ORCID iD: 0000-0003-1936-4448
SPIN-code: 3134-8457

Cand. Sci. (Med.), Ass. Prof.

Russian Federation, 33/1 bld, Vladimirskaya 1st str. 111401, Moscow; Moscow

Irina A. Frolova

State Institution of Health, Moscow region «Bureau of Forensic Medical Examination»; M.F. Vladimirsky Moscow Regional Research Clinical Institute

Email: frolova@sudmedmo.ru
SPIN-code: 5622-8634

Head of the interdistrict histological department

Russian Federation, Moscow; Moscow

Konstantin N. Krupin

State Institution of Health, Moscow region «Bureau of Forensic Medical Examination»

Email: konst.inn@gmail.com
ORCID iD: 0000-0001-6999-8524
SPIN-code: 1761-8559

Cand. Sci. (Med.), Ass. Prof.

Russian Federation, Москва

References

  1. Coronavirus disease (COVID-19) weekly epidemiological update 1 data as received by WHO from national authorities, as of 10am CEST 16 August 2020 [cited 2020 August 17]. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200817-weekly-epi-update-1.pdf?sfvrsn=b6d49a76_4
  2. Coronavirus disease (COVID-19) weekly epidemiological update and weekly operational update [cited 2020 August 17]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/
  3. Rapkiewicz AV, Mai X, Carsons SE, et al. Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series. EClinical Medicine. 2020;6:100434. doi: 10.1016/j.eclinm.2020.100434
  4. Edler C, Schröder AS, Aepfelbacher M, et al. Correction to: Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany. Int J Legal Med. 2020;1:1001–1254. doi: 10.1007/s00414-020-02317-w
  5. Su H, Yang M, Wan C, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney International. 2020;98(1):219–227 doi: 10.1016/j.kint.2020.04.003
  6. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–280. doi: 10.1016/j.cell.2020.02.052
  7. Kogan EA, Berezovsky YS, Protsenko DD, et al. Pathological anatomy of infection caused by SARS-COV-2. Russian Journal of Forensic Medicine. 2020;6(2):8–30. doi: 10.19048/2411-8729-2020-6-2-8-30. (In Russ).
  8. Order of the Ministry of health and social development of the Russian Federation No. 346n of 12.05.2010 «Ob utverzhdenii Poryadka organizatsii i proizvodstva sudebno-medi- tsinskikh ehkspertiz v gosudarstvennykh sudebno-ehkspertnykh uchrezhdeniyakh Rossiiskoi Federatsii». Available from: https://www.garant.ru/products/ipo/prime/doc/12077987/. (In Russ).
  9. Frank GA, Kovalev AV, Gribanov YuP, et al. Issledovanie umershikh s podozreniem na koronavirusnuyu infektsiyu (COVID-19). The provisional guidelines. Version 15 (30.04.2020). Moscow, 2020. (In Russ).
  10. Metodicheskie rekomendatsii po kodirovaniyu i vyboru osnovnogo sostoyaniya v statistike zabolevaemosti i pervonachal’noi prichiny v statistike smertnosti, svyazannykh s COVID-19 (utv. Ministerstvom zdravookhraneniya Rossiiskoi Federatsii 27.05.2020). Available from: https://www.garant.ru/products/ipo/prime/doc/74083741/. (In Russ).
  11. Chernyaev AL, Samsonova MV. Pathological anatomy of lung diseases. Atlas. 2nd revised and updated. Moscow: Atmosphere; 2011. (In Russ).

Copyright (c) 2021 Prikhodko A.N., Maksimov A.V., Frolova I.A., Krupin K.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies