Comparative characteristics of polymorphic allele propagation in the hemostasis system genes PAI-1 (-675 5G/4G) and FGB (-455 G/A) in sudden cardiac death and acute coronary syndrome in patients undergoing coronary artery stenting

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Aim. To give comparative characteristics of the prevalence of polymorphic alleles in the genes of the hemostatic system PAI-1 (-675 5G/4G) and FGB (-455 G/A) in patients with sudden cardiac death and those with acute coronary syndrome undergoing coronary artery stenting. Material and methods. Genetic typing of biological material (BM) was performed for the prevalence of polymorphic alleles in two genes of the hemostasis system. BM was selected from people with a diagnosis of coronary artery disease, divided into three comparison groups: I-suddenly deceased citizens with a diagnosis of coronary artery disease, II-patients with ACS who underwent urgent coronary artery stenting, and III-patients with a chronic form of coronary artery disease in whom endovascular surgery was performed as planned. Results. The calculated criterion χ2 of the prevalence of polymorphisms in the FGB (-455 G/A) and PAI-1 (-675 5G/4G) genes turned out to be more than the critical (tabular) value, which indicates an existing relationship between the presence of IHD and the carriage of one of the polymorphic alleles. Based on the same data, the χ2 criterion was calculated without taking into account data for a group of healthy citizens. For carriers of the polymorphic allele of the FGB gene (-455 G/A), no statistically significant differences were found. For carriers of the PAI-1 gene polymorphic allele (-675 5G/4G), statistically significant differences were found. Conclusions. ACS with a favorable outcome (subject to emergency surgical intervention) occurs at an earlier age than in patients diagnosed with coronary artery disease who die suddenly. The presence of a mutant allele in the PAI-1 gene (-675 5G/4G) requires further studies in order to expertly assess the death rate in patients after surgery with coronary stenting.

About the authors

Dmitriy P. Berezovskiy

I.M. Sechenov First Moscow State University (Sechenov University)

Author for correspondence.
Email: dpb@mail.ru
ORCID iD: 0000-0002-8502-1331
SPIN-code: 4063-5837
Scopus Author ID: 634134

Doc. Sci. (Med.), Ass. prof., I. M. Sechenov First Moscow State University

Russian Federation, Moscow

Irina A. Kolomoets

Rostov State Medical University

Email: ira.kolomoets.73@mail.ru
ORCID iD: 0000-0001-7736-1400
SPIN-code: 5514-9370
Scopus Author ID: 832351

Assistant, Rostov State Medical University

Russian Federation, Rostov-on-Don

Stanislav S. Bachurin

Rostov State Medical University

Email: bachurin_ss@rostgmu.ru
ORCID iD: 0000-0002-4349-5897
SPIN-code: 3150-6795
Scopus Author ID: 780600

Cand. Sci. (Chem.), Rostov State Medical University

Russian Federation, Rostov-on-Don

Vladimir N. Egorov

Rostov State Medical University

Email: suslik78@mail.ru
ORCID iD: 0000-0002-0661-9985
SPIN-code: 6911-1023
Scopus Author ID: 645942

Cand. Sci. (Med.), Ass. Prof., Rostov State Medical University

Russian Federation, Rostov-on-Don

Tatiana V. Tayutina

Rostov State Medical University

Email: tarus76@mail.ru
ORCID iD: 0000-0002-5421-4202
SPIN-code: 7371-6260
Scopus Author ID: 635604

Cand. Sci. (Med.), Ass. Prof., Rostov State Medical University

Russian Federation, Rostov-on-Don

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Copyright (c) 2020 Berezovskiy D.P., Kolomoets I.A., Bachurin S.S., Egorov V.N., Tayutina T.V.

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