Study of the use of compounding drugs in pediatric practice

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Abstract

Aim – study of the use of compounding drugs in pediatric practice.

Material and methods. The objects of the study were official websites, information from the prescription journal of a compounding pharmacy, and instructions for the medical use of drugs. Research methods: content analysis, systematization, generalization, grouping and comparison.

Results. Based on outpatient medical prescriptions of extemporaneous drugs for pediatric patients, the main age categories were identified (children from 1 month to 1 year and from 10 to 12 years). Children from 1 month to 1 year were prescribed powders from ready-made medicines of industrial production (tablets) containing adrenergic blockers in 48% of cases (mainly, propranolol), diuretics – in 31% (spironolactone), PDE5 inhibitors – in 6% (sildenafil). Prescriptions for children aged 10 to 12 years contained in 97% of cases the prescription of eye drops with atropine sulfate from a pharmaceutical substance.

Conclusion. The study of medical prescriptions confirms an individual approach to the treatment of pediatric patients and justifies the need for pharmaceutical compounding of drugs.

About the authors

Marina R. Dudarenkova

Orenburg State Medical University

Author for correspondence.
Email: dfarm88@mail.ru
ORCID iD: 0000-0002-0731-6185

РhD, Associate professor, Associate professor of the Department of Pharmacy Management and Economics, Pharmaceutical Technology and Pharmacognosy

Russian Federation, Orenburg

Anna V. Soloninina

Perm State Pharmaceutical Academy

Email: soloninina@mail.ru
ORCID iD: 0000-0002-2745-7698

PhD, Professor, Head of the Department of Pharmacy Management and Economics

Russian Federation, Perm

Galina Y. Evstifeeva

Orenburg State Medical University

Email: gal-evst@mail.ru
ORCID iD: 0009-0006-9982-4414

PhD, Professor, Head of the Department of Pediatrics

Russian Federation, Orenburg

Ekaterina S. Gorbunova

Orenburg State Medical University

Email: gorbunova_ekaterina_sergeevna@mail.ru
ORCID iD: 0000-0002-2674-1304

senior lecturer of the Department of Pharmacy Management and Economics, Pharmaceutical Technology and Pharmacognosy

Russian Federation, Orenburg

Yuliya U. Nigmatullina

Orenburg State Medical University

Email: poet200707@mail.ru
ORCID iD: 0000-0002-3002-4519

senior lecturer of the Department of Pharmacy Management and Economics, Pharmaceutical Technology and Pharmacognosy

Russian Federation, Orenburg

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Supplementary files

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2. Figure 1. Number of prescriptions received by the pharmacy in January – June 2023.

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3. Figure 2. Age categories of children who have been assigned compounding drugs.

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4. Figure 3. Age of the children who were prescribed compounding drugs.

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5. Figure 4. Age of children under 1 year in months who were prescribed compounding drugs.

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6. Figure 5. Pharmacotherapeutic groups of drugs used for the compounding of dosage forms for children under 1 year.

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Copyright (c) 2024 Dudarenkova M.R., Soloninina A.V., Evstifeeva G.Y., Gorbunova E.S., Nigmatullina Y.U.

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