Email this article THE DISEASE VON HIPPEL-LINDAU TYPE 2C (VHL SYNDROME)IN TWO GENERATIONS OF ONE FAMILY
- Authors: LUKYANOV SA1, SERGYIKO SV2
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Affiliations:
- Челябинская городская клиническая больница №1
- Южно-Уральский государственный медицинский университет
- Issue: Vol 15, No 5-6 (2015)
- Pages: 170-172
- Section: Articles
- URL: https://journals.rcsi.science/2410-3764/article/view/24505
- DOI: https://doi.org/10.17816/2072-2354.2015.0.5-6.170-172
- ID: 24505
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Abstract
The disease von Hippel-Lindau (VHL) is an autosomal dominant inherited disease characterized by predisposition to various cancers. It is caused by a mutation of the 3rd chromosome at the site 3p25/26, where suppression gene of tumor growth is localized. The clinical course of the disease is divided into two types: type 1 - without development of pheochromocytoma (an affection of the retina, tumors of the brain and spinal cord, pancreatic, renal, and splenic cysts, solid pancreatic tumors), type 2 - with the development of pheochromocytoma (subdivided into subtype 2A with a low risk of development of kidney cancer, 2B - high risk of developing kidney cancer, 2C - development of only pheochromocytomas). The paper presents authors’ own observation of the family in two generations with type 2C VHL syndrome.
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##article.viewOnOriginalSite##About the authors
S A LUKYANOV
Челябинская городская клиническая больница №1
Email: 111lll@mail.ru
S V SERGYIKO
Южно-Уральский государственный медицинский университет
Email: ssv_1964@mail.ru
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