PROFESSIONAL RISK AND THE GROWTH FACTORS FGF2, VEGF IN PREDICTING OCCUPATIONAL LUNG DISEASES

The article is investigates occupational risk in workers with prolonged working experience who are exposed to industrial aerosols of varying degrees of fibrogenicity with excessive concentration. Immunological profile of patients with chronic dust bronchitis, silicosis and pneumoconiosis due to the effects of highly dispersed welding aerosols is studied. To solve the set goals and objectives of the study at the clinical stage, 161 people of the contact group, patients with chronic dust bronchitis, silicosis and pneumoconiosis caused by the exposure to highly dispersed welding aerosols were examined. The control group included 60 people. There was also a survey of 304 people with experience of more than 10 years under the influence of high concentrations of industrial fibrogenic aerosols, who underwent an in-depth periodic medical examination at the Regional Center of Occupational Pathology where occupational risk (RR), its etiological fraction (EF) and the ratio of chances (OR) of the development of occupational respiratory diseases were assessed. The features of the course of dust lung diseases, features of the immunological profile, increase in the level of growth factors were established. This allows us to establish the features of the occurrence, course and progression of dust lung diseases, as well as to improve the quality of early diagnosis, optimize prevention strategies for this pathology.

dust lung diseases, professional risk, early diagnosis, immune profile