Balloon microcompression of gasserian ganglion in treatment of patients with trigeminal neuralgia

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Abstract

  • AIM: To determine the group of patients with trigeminal neuralgia for whom the balloon microcompression is the optimal treatment modality. To evaluate the effectiveness of balloon microcompression in the treatment of patients with trigeminal neuralgia.

MATERIALS AND METHODS: The study included 52 patients (18 men and 34 women) with trigeminal neuralgia who were operated with the use of balloon microcompression in neurosurgical department of the Samara Regional Clinical Hospital named after V.D. Seredavin over the period from February 2012 to June 2017. The evaluation of effectiveness was carried by Visual Analogue Scale, Macnub scale, the dose tapering of anti-epileptic medicines was also taken into account.

RESULTS: In postoperative period the decrease in pain syndrome was noticed by 48 patients (92.3%) from 90 ± 10 to 30 ± 10 points by Visual Analogue Scale. According to Macnub scale 29 patients (55.7%) estimated the level of treatment as “good”. 19 patients (36.5%) had negative emotional response due to the hypoesthesia, so the result was estimated as “satisfactory”. 39 patients (75%) managed to decrease the dosage of Finlepsin from 1000-1200 mg to 300-400 mg. Among them there were 8 patients (15%) who subsequently discontinued taking Finlepsin.

CONCLUSIONS: Balloon microcompression of Gasserian ganglion is a destructive-symptomatic method that must be considered the main modality only in patients with idiopathic trigeminal neuralgia or with contraindications for operative treatment. Balloon microcompression of Gasserian ganglion is a minimally destructive treatment mode, which allows to increase the effectiveness of treatment due to the alleviation of pain paroxysm in the area of trigeminal innervation and the decrease in dosage of anti-epileptic medicine.

About the authors

Dmitriy M. Lazarchuk

Samara State Medical University; Samara City Clinical Hospital No. 1 named after N.I. Pirogov

Author for correspondence.
Email: lazarchukmd@yandex.ru

Postgraduate student of the Department of Human Anatomy, Neurosurgeon

Russian Federation, Samara; Samara

Gennadiy N. Alekseev

Samara Regional Clinical Hospital named after V.D. Seredavin

Email: narcenter@inbox.ru

Candidate of Medical Sciences, Head of the Department of Neurosurgery

Russian Federation, Samara

Yuriy V. Suslin

Samara Regional Clinical Hospital named after V.D. Seredavin

Email: suslinyu@mail.ru

Candidate of Medical Sciences, Surgeon of the Department of X-ray Surgical Methods of Diagnosis and Treatment

Russian Federation, Samara

Gleb N. Chernov

Samara State Medical University

Email: gleb.chernov.1998@mail.ru

6th year student

Russian Federation, Samara

Sergey N. Chemidronov

Samara State Medical University

Email: gfrs@inbox.ru

Candidate of Medical Sciences, Associate Professor, Head of the Department of Human Anatomy

Russian Federation, Samara

References

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  2. Gordienko KS. Differencirovannoe mikrohirurgicheskoe lechenie kompressionnyh trigeminal’nyh nevralgij [dissertation abstract]. Saint Petersburg; 2004. (In Russ.)
  3. Lazarchuk DM. Effektivnost’ variantnyh metodov lecheniya nevralgii trojnichnogo nerva. Proceedings of the nauchno-prakticheskaya konferenciya s mezhdunarodnym uchastiem “Aspirantskie chteniya”; 2017, 8 Nov; Samara. Samara, 2017:92–93. (In Russ.)
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  6. Jannetta PJ. Microvascular decompression of the trigeminal nerve root entry zone. In: Trigeminal neuralgia. Ed. by R.L. Rovit, R. Murali, P.J. Jannetta. Baltimore; 1980:201–222.
  7. Katusic S. Williams DB, Beard CM, et al. Epidemiology and clinical features of idiopathic trigeminal neuralgia and glossopharyngeal neuralgia: Similarities and differences, Rochester, 357 Minnesota, 1945-1984. Neuroepidemiology. 199110(5–6):276–281. doi: 10.1159/000110284
  8. Love S, Coakham HB.Trigeminal neuralgia: Pathology and pathogenesis. Brain. 2001;124(Pt 12):2347–2360. doi: 10.1093/brain/124.12.2347

Supplementary files

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2. Fig. 1. Balloon microcompression of Gasserian ganglion

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3. Fig. 2. Fisher’s criterion for treatment outcome. The resulting empirical meaning ϕ* is in the significance zone

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4. Fig. 3. Fisher’s criterion for dose tapering of Finlepsin. The resulting empirical meaning ϕ* is in the significance zone

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Copyright (c) 2021 Lazarchuk D.M., Alekseev G.N., Suslin Y.V., Chernov G.N., Chemidronov S.N.

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