Method optimization for obtaining of “Hawthorn fruit tincture”

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Abstract

The fruits of various species of the genus Crataegus L. contain flavonoids and are widely used in domestic and foreign medicine for the production of cardiotonic drugs. Crataegus submollis Sarg. is grown in our country as the edible and ornamental plant, but it is not currently used in medicine. Fruit juice of Crataegus submollis Sarg. exerts diuretic effect and an antidepressant activity. Dried fruit pulp can be used to produce extraction preparations. The aim of the work is to compare and analyze the samples of tinctures obtained from the fruits of the Crataegus submollis Sarg. and the pulp of its fruits. Tinctures based on 70% ethyl alcohol were obtained on the basis of dried fruits of Crataegus submollis Sarg. and the pulp of its fruits. The quality of the obtained tinctures was studied by determining of the total amount of flavonoids. Tinctures made of dried pulp of Crataegus submollis Sarg. fruits are as good as industrial samples of preparations in terms of flavonoid content. The fruits of the Crataegus submollis Sarg. and the pulp of its fruits can serve as medicinal plant raw materials for obtaining tinctures.

About the authors

Nadezhda A. Volkova

Samara State Medical University

Author for correspondence.
Email: nadezhda_alexandrovna_1997@mail.ru

Postgraduate Student, Department of Pharmacognosy with Botany and the Bases of Phytotherapy

Russian Federation, Samara

Vladimir A. Kurkin

Samara State Medical University

Email: v.a.kurkin@samsmu.ru

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmacognosy with Botany and Bases of Phytotherapy

Russian Federation, Samara

Olga E. Pravdivtseva

Samara State Medical University

Email: pravdivtheva@mail.ru

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmacognosy with Botany and Bases of Phytotherapy

Russian Federation, Samara

Ilnur Kh. Shaikhutdinov

Samara State Medical University

Email: ilshekh@gmail.com

Postgraduate Student, Department of Pharmacognosy with Botany and Bases of Phytotherapy

Russian Federation, Samara

Sergey V. Pervushkin

Samara State Medical University

Email: texnologi-samgmu@yandex.ru

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmaceutical Technology with the Course in Biotechnology

Russian Federation, Samara

Olga V. Ber

Samara State Medical University

Email: texnologi-samgmu@yandex.ru

Candidate of Pharmaceutical Sciences, Associate Professor, Department of Pharmaceutical Technology with the Course in Biotechnology

Russian Federation, Samara

References

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  4. Kurkin VA. Farmakognoziya: uchebnik dlya studentov farmacevticheskikh vuzov. 4-e izd., pererab. i dop. Samara; 2019. (In Russ.)
  5. Kurkin VA, Zajceva EN, Pravdivtseva OE, et al. Fruits of crataegus submollis: study of pharmacological activity of the preparations. Nauka i innivathii v meditsine. 2019;4(3):69–72. (In Russ.). doi: 10.35693/2500-1388-2019-4-3-69-72
  6. Kurkin VA, Pravdivtseva OE, Shaikhutdinov IKh, et al. Vidy roda boyaryshnik (Crataegus L.): standartizatsiya i sozdanie lekarstvennykh preparatov: monografiya. Samara; 2020. (In Russ.)
  7. Kurkina AV. Flavonoidy farmakopeinykh rastenii: monografiya. Samara; 2012. (In Russ.)

Supplementary files

Supplementary Files
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1. JATS XML
2. Figure. Electronic spectra of alcoholic solution of catechin and extract from Crataegus submollis Sarg. fruits: 1 — solution of water-alcohol extraction from Crataegus submollis Sarg. fruits 1:625; 2 — catechin solution in ethyl alcohol 1:8000

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Copyright (c) 2021 Volkova N.A., Kurkin V.A., Pravdivtseva O.E., Shaikhutdinov I.K., Pervushkin S.V., Ber O.V.

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