Email this article Analysis of the cellular immunity status in patients with pathological placentation
- Authors: Berg E.A.1, Yashchuk A.G.1, Musin I.I.1, Naftulovich R.A.1, Popova E.M.1
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Affiliations:
- Bashkir State Medical University
- Issue: Vol 8, No 3 (2021)
- Pages: 167-172
- Section: Original study articles
- URL: https://journals.rcsi.science/2313-8726/article/view/81020
- DOI: https://doi.org/10.17816/2313-8726-2021-8-3-167-172
- ID: 81020
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Abstract
AIM: The study aimed to investigate the cellular immunity in patients with placental disposition.
MATERIALS AND METHODS: A prospective study analyzed birth histories and clinical and laboratory parameters of 10 patients with placental disposition. The cellular immunity status was determined by analyzing lymphocytes with a cluster of differentiation (CD), including CD3+, CD4+, CD8+, CD16+56, CD3-СD8+, TNK, and CD38+8+. Obtained data were analyzed statistically.
RESULTS: Patients were 32.0 (29.0; 36.0) years old. As regards reproductive history, 60.0% had a history of three pregnancies, 20% had two pregnancies, 10% had their first pregnancy, and 10% had their fourth pregnancy. Moreover, placenta dispositions most often occurred at the second pregnancy in 70.0%, at the third pregnancy in 20.0%, and first pregnancy in 10%. In terms of cell immunity in comparison with normal indicators, the relative number of natural killer cells (CD16+56+), including activated CD3-СD8+, tended to increase. A relative increase in cytotoxic T-lymphocytes (СD8+) was found against the background of lower number of T-helper cells, along with general immunodeficiency (immunoregulatory index in the absolute number of women was less than 1.5).
CONCLUSIONS: Further investigation of cellular immunity in women with placental pathology is relevant to detect additional pathogenetic mechanisms of the development of obstetric complications.
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##article.viewOnOriginalSite##About the authors
Edvard A. Berg
Bashkir State Medical University
Email: aig.eaberg@gmail.com
ORCID iD: 0000-0002-2028-7796
assistant at Department of Obstetrics and Gynecology
Russian Federation, 3 Lenin Str., Ufa, 450008Alfiya G. Yashchuk
Bashkir State Medical University
Email: alfiya_galimovna@mail.ru
ORCID iD: 0000-0003-2645-1662
MD, Dr. Sci. (Med.), Professor, Head Obstetrics and Gynecology Department
Russian Federation, 3 Lenin Str., Ufa, 450008Il’nur I. Musin
Bashkir State Medical University
Author for correspondence.
Email: ilnur-musin@yandex.ru
ORCID iD: 0000-0001-5520-5845
MD, Cand. Sci. (Med.), Associate Professor of Department of Obstetrics and Gynecology
Russian Federation, 3 Lenin Str., Ufa, 450008Raisa A. Naftulovich
Bashkir State Medical University
Email: aig.eaberg@gmail.com
ORCID iD: 0000-0003-2893-4844
MD, Cand. Sci. (Med.), Associate Professor of Department of Obstetrics and Gynecology
Russian Federation, 3 Lenin Str., Ufa, 450008Elena M. Popova
Bashkir State Medical University
Email: aig.eaberg@gmail.com
assistant at Department of Obstetrics and Gynecology
Russian Federation, 3 Lenin Str., Ufa, 450008References
- Thurn L, Wide-Swensson D, Hellgren-Wångdahl M. Postpartum blödningar med blod transfusioner har ökat [Postpartum hemorrhage and need of blood transfusions]. Lakartidningen. 2021;118:20147. (In Swedish).
- Pradhan S, Tuladhar A, Shrestha A, Amatya NB, Pradhan P. Sonographic assessment of placental migration in second trimester low lying placenta. Nepal Med Coll J. 2012;14(4):331–333.
- Laban M, Ibrahim EA-S, Elsafty MSE, Hassanin AS. Placenta accreta is associated with decreased decidual natural killer (dNK) cells population: a comparative pilot study. Eur J Obstet Gynecol Reprod Biol. 2014;181:284–288. doi: 10.1016/j.ejogrb.2014.08.015
- Renaud SJ, Scott RL, Chakraborty D, Rumi MAK, Soares MJ. Natural killer-cell deficiency alters placental development in rat. Biol Reprod. 2017;96(1):145–158. doi: 10.1095/biolreprod.116.142752
- Sliz A, Locker KCS, Lampe K, et al. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Sci Immunol. 2019;4(38):eaav3866. doi: 10.1126/sciimmunol.aav3866
- Mikhailova VA, Belyakova KL, Selkov SA, Sokolov DI. Peculiarities of NK cells differentiation: CD56dim and CD56bright NK cells at pregnancy and in non-pregnant state. Medical Immunology (Russia). 2017;19(1):19–26. (In Russ). doi: 10.15789/1563-0625-2017-1-19-26
- Yarets Yu.I. Interpretation of the results of the immunogram. Gomel: Respublikanskii nauchno-prakticheskii tsentr radiatsionnoi meditsiny i ekologii cheloveka; 2020. 38 p. (In Russ).
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