Email this article Cytokine status and availability of vitamin d in women with miscarriage of infectious genesis
- Authors: Savchenko T.N.1, Ozolinya L.A.1, Dergacheva I.A.1, Polovinkina E.N.1, Safonina M.S.1
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Affiliations:
- N.I. Pirogov Russian National Research Medical University
- Issue: Vol 7, No 3 (2020)
- Pages: 153-157
- Section: Original study articles
- URL: https://journals.rcsi.science/2313-8726/article/view/44843
- DOI: https://doi.org/10.17816/2313-8726-2020-7-3-153-157
- ID: 44843
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Abstract
In recent years, there have been reports of the role of vitamin D deficiency in the development of inflammatory processes of various localization associated with the prolonged persistence of infectious agents and its effect on the implementation of the immune response.
The objective — to assess the condition of cytokine status and the availability of vitamin D in pregnant women with miscarriage and urogenital infection to improve prognostications and prevention of complications in obstetrics.
Material and methods. We examined 106 pregnant women in the I–II trimester of pregnancy: 76 pregnant women with miscarriage (the main group) and 30 women with a physiological pregnancy progression (the control group) with the determination of their serum vitamin D level by high-performance liquid chromatography (HPLC), diagnostics of urogenital infection and immunity indicators with the determination of serum cytokines.
Results and discussion. According to the results of the study, it was found that the level of vitamin D in the blood below 20 ng/ml is more often accompanied by miscarriage. Correlation analysis confirmed the presence of a relationship between cytokine production and the level of vitamin D in the blood of pregnant women.
Conclusion. Normalization of vitamin D levels in the blood can help to reduce the risk of miscarriage.
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##article.viewOnOriginalSite##About the authors
Tat’yana N. Savchenko
N.I. Pirogov Russian National Research Medical University
Email: 12111944t@mail.ru
ORCID iD: 0000-0001-7244-4944
SPIN-code: 3157-3682
MD, PhD, Professor
Russian Federation, MoscowLyudmila A. Ozolinya
N.I. Pirogov Russian National Research Medical University
Author for correspondence.
Email: ozolinya@yandex.ru
ORCID iD: 0000-0002-2353-123X
SPIN-code: 9407-9014
MD, Ph.D., DSci., Professor of the Department of Obstetrics and Gynecology, Medical Faculty of the N.I. Pirogov Russian National Research Medical University
Russian Federation, MoscowIrina A. Dergacheva
N.I. Pirogov Russian National Research Medical University
Email: iraignatenko@mail.ru
ORCID iD: 0000-0002-3049-6954
SPIN-code: 5135-8612
Russian Federation, Moscow
Ekaterina N. Polovinkina
N.I. Pirogov Russian National Research Medical University
Email: polowinkinakaterina@yandex.ru
ORCID iD: 0000-0002-0686-2790
SPIN-code: 2494-9131
Russian Federation, Moscow
Marina S. Safonina
N.I. Pirogov Russian National Research Medical University
Email: marixie.s@gmail.com
ORCID iD: 0000-0003-4252-4024
SPIN-code: 2997-4580
Russian Federation, Moscow
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