ATYPICAL HEMOLYTIC-UREMIC SYNDROME DURING PREGNANCY. PRESENT AND LATEST RESULTS OF TREATMENT


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Abstract

Atypical hemolytic-uremic syndrome being referred to autoimmune diseases appears to be one of the most severe forms of thrombosis and microangiopathy. Difficulties in diagnosis cause a delay in pathogenetic therapy, which causes a high maternal mortality rate. Pathogenetic therapy with eculizumab, suppressing the terminal activity of complement, may contribute to the recovery of blood coagulation properties, but the long-term prognosis for chronic renal failure remains unfavorable. The article deals with a clinical case confirming this conclusion.

About the authors

N. A Zharkin

Volgograd State Medical University, Ministry of Health of Russia

Volgograd, 400131, Russian Federation

M. E Statsenko

Volgograd State Medical University, Ministry of Health of Russia

Volgograd, 400131, Russian Federation

M. M Stazharova

Volgograd Regional Clinical Hospital No. 1

Volgograd, 400081, Russian Federation

Natalia A. Burova

Volgograd State Medical University, Ministry of Health of Russia

Email: natalia-burova@yandex.ru
MD, Ph.D., Associate Professor, Department of Obstetrics and Gynecology, Volgograd State Medical University, Volgograd, 400131, Russian Federatio Volgograd, 400131, Russian Federation

S. A Prokhvatilov

Volgograd Regional Clinical Hospital No. 1

Volgograd, 400081, Russian Federation

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