Unusual clinical case: Pharmabortion in a patient with a donor kidney

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Abstract

The study presents an algorithm for drug-induced abortion and prevention of complications after the procedure, with a clinical efficacy rate of 99.7%. In addition, a unique case is presented, involving the use of drugs to terminate a short-term pregnancy in a patient with chronic glomerulonephritis that affecting her kidney and chronic pyelonephritis in a previously transplanted second kidney. Given the lack of urinary organ dysfunction and the absence of clinical worsening of any somatic pathology at present, the medical consilium has determined that pharmabortion is permissible under dynamic monitoring of the patient. A single oral dose of 600 mg of mifepristone, followed by twice-daily administration of 400 mcg of misoprostol (per os) 36 h later, effectively terminated the unwanted pregnancy without adverse effects on extragenital diseases. Administering the gestagenic drug during the second phase of the menstrual cycle after abortion prevented ovarian dysfunction and endometrial hyperplasia.

About the authors

Sergey P. Sinchikhin

Astrakhan State Medical University; Razumovsky Saratov State Medical University

Author for correspondence.
Email: doc_sinchihin@mail.ru
ORCID iD: 0000-0001-6184-1741

MD, Dr. Sci. (Med.), Professor, Head of the Department of Obstetrics and Gynecology

Russian Federation, Astrakhan; Saratov

Olga E. Nagaeva

City Polyclinic No. 10

Email: arbuz81@yandex.ru
ORCID iD: 0000-0002-9741-7501

Head of the Antenatal Clinic

Russian Federation, Astrakhan

Ekaterina S. Sinchikhina

Astrakhan State Medical University

Email: es.sinchikhina@mail.ru
ORCID iD: 0000-0002-3949-4349

Student

Russian Federation, Astrakhan

Margarita D. Mustafaeva

Astrakhan State Medical University

Email: arbuz2303@yandex.ru
ORCID iD: 0000-0003-3496-8960

Сlinical Resident

Russian Federation, Astrakhan

References

  1. Serov VN, Sukhikh GT, Prilepskaya VN, Radzinskii VE, editors. Guidelines for outpatient care in obstetrics and gynecology. Moscow: GEOTAR-Media; 2016. 1136 p. (In Russ).
  2. Sinchikhin SP. Algorithm for medical abortion and post-abortion rehabilitation. Reproductive health of children and adolescents. 2008;(2):43–50. (In Russ).
  3. Sukhikh GT, Serov VN, Prilepskaya VN, et al. Medical termination of pregnancy. Clinical Guidelines (treatment protocol). Moscow: Ministry of Health of Russia; 2015. (In Russ).
  4. Dikke GB. Medical abortion. A guide for doctors / Radzinskii VE, ed. Moscow: MEDpress-inform; 2015. (In Russ).
  5. Sinchikhin SP, Mamiev OB. Evaluation of the effectiveness of the algorithm for medical termination of pregnancy and post-abortion rehabilitation. Gynecology. 2008;10(1):56–60. (In Russ).

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