Clinical experience with postpartum treatment of a patient with arteriovenous malformation of uterine vessels

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Abstract

Uterine arteriovenous malformation is a rare vascular dysplasia where the uterine veins communicate with the branches of arteries of varying calibers. Patient K., a 37-years-old patient, presented with genital tract bleeding. Her medical history included operative labor at 37 weeks with dichorionic diamniotic twins, with the placental site on the posterior uterine wall exhibited firm attachment. The uterine cavity walls were scraped, and the bleeding vessel in the placental site was sutured. The blood loss amounted to 750 mL, and reinfusion was conducted. Fourteen days after giving birth, a heavy bloody discharge with blood clots from the genital tract occurred. The blood tests revealed no abnormalities. Echography detected multiple tubular structures that were anechoic on the posterior wall of the uterus, from the endometrium to the serosa, with the CDC mode blood flow. Magnetic resonance angiography revealed hypervascularization with premature arteriovenous discharge. Superselective embolization was performed on uterine artery afferents, and complete blood flow reduction was achieved, leading to the cessation of bleeding. On postoperative day 17, the patient experienced considerable bloody discharge from the genital tract, causing the hemoglobin level to decrease to 88 g/L. The presence of an arteriovenous malformation in the uterine vessels accompanied by ineffective embolization necessitated uterine extirpation. The postoperative phase was uneventful, and the patient was discharged from the hospital in satisfactory condition, with no evidence of anemia (hemoglobin, 115 g/L).

About the authors

Liliya A. Busygina

Zhukovskaya City Clinical Hospital

Email: busyginala@mosreg.ru
ORCID iD: 0009-0003-8085-7863

Chief Medical Officer

Russian Federation, Zhukovsky, Moscow Region

Ol’ga F. Serova

Moscow Regional Perinatal Center

Email: mopc02@mail.ru
ORCID iD: 0000-0002-4088-4619

MD, Dr. Sci. (Med.), Professor

Russian Federation, Balashikha, Moscow Region

Liliya R. Garaeva

Zhukovskaya City Clinical Hospital

Email: garaevlil@mail.ru
ORCID iD: 0009-0003-2318-1377

MD, Cand. Sci. (Med.)

Russian Federation, Zhukovsky, Moscow Region

Kamil’ R. Bakhtiyarov

Zhukovskaya City Clinical Hospital

Email: doctorbah@mail.ru
ORCID iD: 0000-0002-3176-5589

MD, Dr. Sci. (Med.), Professor

Russian Federation, Zhukovsky, Moscow Region

Abdurahman К. Isaev

Zhukovskaya City Clinical Hospital

Author for correspondence.
Email: isaev.doc@mail.ru
ORCID iD: 0009-0000-9520-9357

MD, Dr. Sci. (Med.), Head of the Department

Russian Federation, Zhukovsky, Moscow Region

Irina V. Barinova

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: mz_moniiag@mosreg.ru
ORCID iD: 0000-0003-0447-1734

MD, Dr. Sci. (Med.)

Russian Federation, Moscow

Abror O. Abdullazhonov

Zhukovskaya City Clinical Hospital

Email: abror.abdullajono96@mail.ru
ORCID iD: 0009-0009-7612-8725

Doctor, Endovascular Surgeon

Russian Federation, Zhukovsky, Moscow Region

References

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  4. Aiyappan SK, Ranga U, Veeraiyan S. Doppler sonography and 3D CT angiography of acquired uterine arteriovenous malformations (AVMs): report of two cases. J Clin Diagn Res. 2014;8(2):187–189. doi: 10.7860/JCDR/2014/6499.4056
  5. Lin AC, Hung YC, Huang LC, Chiu TH, Ho M. Successful treatment of uterine arteriovenous malformation with percutaneous embolization. Taiwan J Obstet. Gynecol. 2007;46(1):60–63. doi: 10.1016/S1028
  6. Valenzano M, Foglia G, Tedeschi C, Paoletti R, Fulcheri E. Color Doppler sonography of uterine arteriovenous malformation. J Clin Ultrasound. 2000;28(3):146–149. doi: 10.1002/(sici)1097

Supplementary files

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2. Fig. 1. Ultrasound picture of arteriovenous malformation of the uterus.

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3. Fig. 2. Contrast of arteriovenous malformation (highlighted in color) from the right (a) and left (b) uterine artery.

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4. Fig. 3. Results of superselective embolization of afferents from the right (a) and left (b) uterine arteries.

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5. Fig. 4. Macropreparation of arteriovenous malformation of uterine vessels.

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6. Fig. 5. Pathologically altered venous-type vessel in the submucosal parts of the myometrium and regenerating mucosa of the uterine body (×25): a ― a vein with a thickened wall, represented mainly by fibrous tissue (Van Gieson coloration); b ― randomly located actin-positive smooth muscle cells in the thickened lower part of the vein, smooth muscle fibers of the myometrium in the thin upper part; immunohistochemical reaction with antibodies to alpha-smooth muscle actin.

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