Individual tolerance to hypoxia: indicators, application and methods of determination

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Relevance . Human resistance to hypoxia is the most important characteristic of the organism that determines its performance, risk of development and severity of cardiovascular, pulmonological and neurodegenerative diseases. Hypoxia, being a typical pathological process, is one of the key links in the pathogenesis of many acute and chronic conditions, leading to delayed consequences and significantly reducing the quality of life of patients. Hypoxic tolerance is determined by many factors, including genetic features, physiological mechanisms and external conditions. Various methods such as hypoxia tests, functional tests, etc. are used to determine individual tolerance to hypoxia. These methods make it possible to assess the degree of the organism’s tolerance to hypoxia and to determine optimal training and treatment regimes. The study of correlations between individual sensitivity indices and hypoxic resistance is widely covered in the literature, but in most cases, authors pay attention to one or several aspects of these interactions, without conducting a comprehensive analysis of various indicators. The purpose of the study is to actualize and structure the available information on the indicators of individual sensitivity to hypoxia, methods of objective assessment of human hypoxia resistance, as well as the applied significance of this characteristic of the human organism for clinical medicine and related sciences. Research Methods. The team of authors conducted a content analysis of domestic and foreign scientific publications in Russian and international databases. Results and Discussion . A consistent structural analysis of the available current data on indicators of hypoxic resistance and their relationship with hypoxic resistance is presented. Variations in the methods of hypoxic resistance determination currently used in clinical practice are considered. Conclusion. The literature review on the topic of individual hypoxia tolerance shows that the study of this phenomenon is an actual and multifaceted direction of modern science. Complex evaluation of individual hypoxia tolerance indicators will allow to predict the patient’s organism reaction to hypoxia accurately enough before the instrumental examination, and also will allow to rethink modern instrumental methods of evaluation and increase of organism resistance to hypoxia, widely used in clinical and sports medicine.

Sobre autores

Andrey Venerin

Sechenovskiy University

Autor responsável pela correspondência
Email: venerin.andrey@gmail.com
ORCID ID: 0000-0002-8960-5772
Código SPIN: 8881-1892
Moscow, Russian Federation

Maxim Zapara

Sechenovskiy University

Email: venerin.andrey@gmail.com
ORCID ID: 0000-0003-2639-6253
Código SPIN: 2025-4697
Moscow, Russian Federation

Alina Mikhalishchina

Sechenovskiy University

Email: venerin.andrey@gmail.com
ORCID ID: 0000-0003-4028-6405
Código SPIN: 2134-6830
Moscow, Russian Federation

David Pupo Macharashvili

Sechenovskiy University

Email: venerin.andrey@gmail.com
ORCID ID: 0009-0002-4763-5321
Moscow, Russian Federation

Oleg Glazachev

Sechenovskiy University

Email: venerin.andrey@gmail.com
ORCID ID: 0000-0001-9960-6608
Código SPIN: 6168-2110
Moscow, Russian Federation

Bibliografia

  1. Post TE, Heijn LG, Jordan J, van Gerven JMA. Sensitivity of cognitive function tests to acute hypoxia in healthy subjects: a systematic literature review. Front Physiol. 2023;14:1244279. doi: 10.3389/fphys.2023.1244279
  2. Ravi R, Subhan MMF. The effects of acute hypoxia on cognitive and cardiovascular parameters in healthy subjects. Acad Biol. 2023:1—11. doi: 10.20935/AcadBiol6070
  3. Chen PS, Chiu WT, Hsu PL, Lin SC, Peng IC, Wang CY, Tsai SJ. Pathophysiological implications of hypoxia in human diseases. J Biomed Sci. 2020;27(1):63. doi: 10.1186/s12929-020-00658-7
  4. Brüne B, Zhou J. Nitric oxide and superoxide: Interference with hypoxic signaling. Cardiovasc Res. 2007;75(2):275—282. doi: 10.1016/j.cardiores.2007.03.005
  5. Nourkami-Tutdibi N, Küllmer J, Dietrich S, Monz D, Zemlin M, Tutdibi E. Serum vascular endothelial growth factor is a potential biomarker for acute mountain sickness. Front Physiol. 2023;14:1083808. doi: 10.3389/fphys.2023.1083808
  6. Kumar A, Vaish M, Karuppagounder SS, Gazaryan I, Cave JW, Starkov AA, Anderson ET, Zhang S, Pinto JT, Rountree AM, Wang W, Sweet IR, Ratan RR. HIF1α stabilization in hypoxia is not oxidant-initiated. Elife. 2021;10: e72873. doi: 10.7554/eLife.72873
  7. Mallet RT, Burtscher J, Pialoux V, Pasha Q, Ahmad Y, Millet GP, Burtscher M. Molecular Mechanisms of High-Altitude Acclimatization. Int J Mol Sci. 2023;24(2):1698. doi: 10.3390/ijms24021698
  8. Chrishtop V V., Rumyantseva TA, Nikonorova VG. Typological features of the brain in normal conditions and in cerebral hypoperfusion. RUDN Journal of Medicine. 2020;24(4):345—353. (in Russian) doi: 10.22363/2313-0245-2020-24-4-345-353
  9. Guseynov NA, Ivashkevich SG, Boyko EM. Physiological features of cells and microvasculature under the local hypothermia influence. RUDN Journal of Medicine. 2022;26(1):34—41. (in Russian) doi: 10.22363/2313-0245-2022-26-1-34-41
  10. Guicciardi M, Pazzona R, Manca A, Monni A, Scalas LF, Perra F, Leban B, Roberto S, Mulliri G, Ghiani G, Doneddu A, Crisafulli A. Executive Functions and Mood States in Athletes Performing Exercise Under Hypoxia. Front Psychol. 2022;13:1—10. doi: 10.3389/fpsyg.2022.906336
  11. Dzhalilova D, Makarova OV. The Role of Hypoxia-Inducible Factor in the Mechanisms of Aging. Biochem. 2022;87(9):995—1014. doi: 10.1134/S0006297922090115
  12. Rybnikova E, Nalivaeva N. Glucocorticoid-Dependent Mechanisms of Brain Tolerance to Hypoxia. Int J Mol Sci. 2021;22(15):7982. doi: 10.3390/ijms22157982
  13. Mosset IB, Gonchar AL, Kukhtinskaya LV, Mosset NI, Malashevich PN, Semenyakov AV. Genetic markers of organism resistance to hypoxia. Molecular and applied genetics. 2010;11:74—82. (in Russian)
  14. Dzhalilova D, Makarova O. Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics. Biomedicines. 2020;8(10):428. doi: 10.3390/biomedicines8100428
  15. Gong H, Tashkin DP, Lee EY, Simmons MS. Hypoxia-altitude simulation test. Evaluation of patients with chronic airway obstruction. Am Rev Respir Dis. 1984;130(6):980—986. doi: 10.1164/arrd.1984.130.6.980
  16. Zelenkova IE, Zotkin SV, Korneev PV, Koprov SV, Almyashev DH, Glazachev OS, Grushin AA. Нypoxic tolerance variability in athletes with different training level and sports specialization. Sport Med Res Pract. 2016;4:5—10. (in Russian) doi: 10.17238/ISSN2223—2524.2016.4.5
  17. Shiryaeva A, Fateev I, Kuz’min A, Vetryakov O, Shkarupa A. Modern methodological approaches to the assessment of hypoxia tolerance and physical working capacity prediction in the mountains (literature review). Univ proceedings Volga Reg Med Sci. 2022;(4). (in Russian) doi: 10.21685/2072-3032-2022-4-11
  18. Glazachev OS, Geppe NA, Timofeev YS, Samarceva VG, Dudnik EN, Zapara MA, Chebysheva SN. Indicators of individual hypoxia resistance — a way to optimize hypoxic training for children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2020;65(4):78—84. (in Russian) doi: 10.21508/1027-4065-2020-65-4-78-84
  19. Lefferts WK, Babcock MC, Tiss MJ, Ives SJ, White CN, Brutsaert TD, Heffernan KS. Effect of hypoxia on cerebrovascular and cognitive function during moderate intensity exercise. Physiol Behav. 2016;165:108—118. doi: 10.1016/j.physbeh.2016.07.003
  20. Burtscher J, Niedermeier M, Hüfner K, van den Burg E, Kopp M, Stoop R, Burtscher M, Gatterer H, Millet GP. The interplay of hypoxic and mental stress: Implications for anxiety and depressive disorders. Neurosci Biobehav Rev. 2022;138:104718. doi: 10.1016/j.neubiorev.2022.104718
  21. Burtscher J, Mallet RT, Burtscher M, Millet GP. Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Res Rev. 2021;68:101343. doi: 10.1016/j.arr.2021.101343
  22. Glazachev OS, Lyamina NP, Spirina GK. Intermittent hypoxic conditioning: experience and potential in cardiac rehabilitation programs. Russ J Cardiol. 2021;26(5):4426. (in Russian) doi: 10.15829/1560-4071-2021-4426
  23. Glazachev OS, Kryzhanovskaya SJ. Adaptation medicine: human adaptation to critically changed environment. Bulletin of the international academy of sciences. 2019;1:48—55. (in Russian)
  24. Dominelli PB, Molgat-Seon Y. Sex, gender and the pulmonary physiology of exercise. Eur Respir Rev. 2022;31(163):210074. doi: 10.1183/16000617.0074-2021
  25. Karayigit R, Eser MC, Sahin FN, Sari C, Sanchez-Gomez A, Dominguez R, Koz M. The Acute Effects of Normobaric Hypoxia on Strength, Muscular Endurance and Cognitive Function: Influence of Dose and Sex. Biology (Basel). 2022;11(2):309. doi: 10.3390/biology11020309
  26. Burtscher J, Raberin A, Brocherie F, Malatesta D, Manferdelli G, Citherlet T, Krumm B, Bourdillon N, Antero J, Rasica L, Burtscher M, Millet GP. Recommendations for Women in Mountain Sports and Hypoxia Training/Conditioning. Sport Med. 2023. doi: 10.1007/s40279-023-01970-6
  27. Albertus-Cámara I, Rochel-Vera C, Lomas-Albaladejo JL, Ferrer-López V, Martínez-González-Moro I. Ventilatory Pattern Influences Tolerance to Normobaric Hypoxia in Healthy Adults. Int J Environ Res Public Health. 2023;20(6):4935. doi: 10.3390/ijerph20064935
  28. Soliz J, Thomsen JJ, Soulage C, Lundby C, Gassmann M. Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin. Am J Physiol Integr Comp Physiol. 2009;296(6): R1837-R1846. doi: 10.1152/ajpregu.90967.2008
  29. Mandel IA, Kiselev VO, Podoksenov YK, Svirko YS, Shipulin VM. Hypoxic test as a method of predicting haemotransfusion tactics and the course of early postoperative period in coronary surgery. Pathology of Circulation and Cardiac Surgery. 2012;16(2):71—76. (in Russian) doi: 10.21688/1681-3472-2012-2-71-76
  30. Krivoshchekov SG, Balioz NV, Nekipelova NV, Kapilevich LV. Age, gender, and individually-typological features of reaction to sharp hypoxic influence. Human Physiology. 2014;40(6):34—45. doi: 10.7868/S013116461406006X (in Russian)
  31. Botek M, Krejčí J, De Smet S, Gába A, McKune AJ. Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia. Auton Neurosci Basic Clin. 2015;190:40—45. doi: 10.1016/j.autneu.2015.04.001
  32. Botek M, Krejčí J, McKune A. Sex Differences in Autonomic Cardiac Control and Oxygen Saturation Response to Short-Term Normobaric Hypoxia and Following Recovery: Effect of Aerobic Fitness. Front Endocrinol (Lausanne). 2018;9:697. doi: 10.3389/fendo.2018.00697
  33. Bai J, Li L, Li Y, Zhang L. Genetic and immune changes in Tibetan high-altitude populations contribute to biological adaptation to hypoxia. Environ Health Prev Med. 2022;27:22—00040. doi: 10.1265/ehpm.22-00040
  34. Nam HJ, Baek SH. Epigenetic regulation of the hypoxic response. Curr Opin Physiol. 2019;7:1—8. doi: 10.1016/j.cophys.2018.11.007
  35. Krivoshchekov SG, Kovtun LT, Nekipelova NV. Response of cardiorespiratory system of healthy people to hypoxic exposure depending on psychophysiological characteristics. Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences. (in Russian) 2010;30(4):14—18.
  36. Ahmedzai S, Balfour-Lynn IM, Bewick T, Buchdahl R, Coker RK, Cummin AR, Gradwell DP, Howard L, Innes JA, Johnson AO, Lim E, Lim WS, McKinlay KP, Partridge MR, Popplestone M, Pozniak A, Robson A, Shovlin CL, Shrikrishna D, Simonds A, Tait P, Thomas M; British Thoracic Society Standards of Care Committee. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax. 2011;66(Suppl 1): i1‑i30. doi: 10.1136/thoraxjnl‑2011—200295
  37. Balfour-Lynn IM. Hypoxic Challenge Test for airflight in children with respiratory disease. Paediatr Respir Rev. 2017;21:62—64. doi: 10.1016/j.prrv.2016.05.002
  38. Lhuissier FJ, Brumm M, Ramier D, Richalet JP. Ventilatory and cardiac responses to hypoxia at submaximal exercise are independent of altitude and exercise intensity. J Appl Physiol. 2012;112(4):566—570. doi: 10.1152/japplphysiol.00906.2011
  39. Pla R, Brocherie F, Le Garrec S, Richalet J. Effectiveness of the hypoxic exercise test to predict altitude illness and performance at moderate altitude in high-level swimmers. Physiol Rep. 2020;8(8): e14390. doi: 10.14814/phy2.14390
  40. Shatylo VB, Serebrovska TV, Gavalko AV, Egorov E, Korkushko OV. Acute Hypoxic Test in Patients with Prediabetes. High Alt Med Biol. 2016;17(2):101—107. doi: 10.1089/ham.2015.0117
  41. Alameeri A, Ur Rasool M, Wynne O, Subramaniam A, Moloney E, Lane SJ. Time to improve training for hypoxic pulmonary challenge test. QJM An Int J Med. 2019;112(4):309—309. doi: 10.1093/qjmed/hcy121
  42. Rooney D, Herkenrath S, Priegnitz C, Putzke M, Treml M, Wenzel J, Aeschbach D, Randerath W. Choosing an Adequate Test to Determine Fitness for Air Travel in Obese Individuals. Chest. 2019;156(5):926—932. doi: 10.1016/j.chest.2019.07.022
  43. Glazachev OS, Geppe NA, Timofeev IS, Shahnazarova MD, Kolosova NG, Samarceva VG, Dudnik EN, Malahov AB, Frolkova EV, Kalinovskaya II. Features of hypoxic resistance in children with bronchial asthma who have undergone a new coronavirus infection. Pediatr Cons Medicum. 2021;(2):152—157. (in Russian) doi: 10.26442/26586630.2021.2.200881
  44. Mandel IA, Podoksenov YK, Mikheev SL, Suhodolo IV, Svirko YS, Shipulin VM, Ivanova AV, Yavorovskiy AG, Yaroshetskiy AI. Endothelial Function and Hypoxic–Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial. Biomedicines. 2023;11(4):1044. doi: 10.3390/biomedicines11041044
  45. Romanov KP, Yusupov RA, Kozlov AV. Load testing as a method of determining athlete’s tolerance to the normobaric hypoxia. Physical culture and health. 2020;(4):141—144. (in Russian) doi: 10.47438/1999-3455_2020_4_141
  46. Maleev D. Defining a highly skilled ski-racer’s body individual resistance to acute hypoxia. Bull South Ural State Univ Ser Educ Heal Phys Cult. 2015;15(4):19—23. (in Russian) doi: 10.14529/ozfk150403
  47. Semenov DG, Belyakov AV, Rybnikova EA. Experimental modeling of damaging and protective hypoxia of the mammalian brain. Russian journal of physiology. 2022;108(12):1592—1609. (in Russian) doi: 10.31857/S086981392212010X
  48. Jung M, Zou L, Yu JJ, Ryu S, Kong Z, Yang L, Kang M, Lin J, Li H, Smith L, Loprinzi PD. Does exercise have a protective effect on cognitive function under hypoxia? A systematic review with meta-analysis. J Sport Heal Sci. 2020;9(6):562—577. doi: 10.1016/j.jshs.2020.04.004
  49. Rybnikova EA, Nalivaeva NN, Zenko MY, Baranova KA. Intermittent Hypoxic Training as an Effective Tool for Increasing the Adaptive Potential, Endurance and Working Capacity of the Brain. Front Neurosci. 2022;16:941740. doi: 10.3389/fnins.2022.941740
  50. Bilo G, Gatterer H, Torlasco C, Villafuerte FC, Parati G. Editorial: Hypoxia in cardiovascular disease. Front Cardiovasc Med. 2022;9:990013. doi: 10.3389/fcvm.2022.990013
  51. Navarrete-Opazo A, Mitchell GS. Therapeutic potential of intermittent hypoxia: A matter of dose. Am J Physiol — Regul Integr Comp Physiol. 2014;307(10): R1181-R1197. doi: 10.1152/ajpregu.00208.2014
  52. Glazachev O, Kopylov P, Susta D, Dudnik E, Zagaynaya E. Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study. Clin Cardiol. 2017;40(6):370—376. doi: 10.1002/clc.22670
  53. Muangritdech N, Hamlin MJ, Sawanyawisuth K, Prajumwongs P, Saengjan W, Wonnabussapawich P, Manimmanakorn N, Manimmanakorn A. Hypoxic training improves blood pressure, nitric oxide and hypoxia-inducible factor‑1 alpha in hypertensive patients. Eur J Appl Physiol. 2020;120(8):1815—1826. (in Russian) doi: 10.1007/s00421-020-04410-9
  54. Samoilov VO, Maksimov AL, Filippova EB, Korolev YN, Golubev VN, Golovina AS, Savokina OV, Lesova EM. Characteristics of individual differences of human functional state in hypoxic hypoxia. Bulletin of the Russian Military Medical Academy. 2013;3(43):1—7. (in Russian)
  55. Lukyanova LD, Kirova YI, Sukoyan GV. Signalling mechanisms of adaptation to hypoxia and their role in system regulation. Biological Membranes. 2012;29(4):238—252. [Лукьянова Л.Д., Кирова Ю.И., Сукоян Г.В. Сигнальные механизмы адаптации к гипоксии и их роль в системной регуляции // Биологические мембраны. 2012. Т. 29. № 4. С. 238—252.]
  56. George PM, Orton C, Ward S, Menzies-Gow A, Hull JH. Hypoxic Challenge Testing for Fitness to Fly with Severe Asthma. Aerosp Med Hum Perform. 2016;87(6):571—574. doi: 10.3357/AMHP.4543.2016
  57. Uzun AB, Iliescu MG, Stanciu LE, Ionescu EV, Ungur RA, Ciortea VM, Irsay L, Motoașcă I, Popescu MN, Popa FL, Pazara L, Tofolean DE. Effectiveness of Intermittent Hypoxia–Hyperoxia Therapy in Different Pathologies with Possible Metabolic Implications. Metabolites. 2023;13(2):181. doi: 10.3390/metabo13020181
  58. Serebrovska ZO, Serebrovska TV., Kholin VA, Tumanovska LV, Shysh AM, Pashevin DA, Goncharov SV, Stroy D, Grib ON, Shatylo VB, Bachinskaya NY, Egorov E, Xi L, Dosenko VE. Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study. Int J Mol Sci. 2019;20(21):5405. doi: 10.3390/ijms20215405
  59. Wang H, Shi X, Schenck H, Hall JR, Ross SE, Kline GP, Chen S, Mallet RT, Chen P. Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study. Am J Alzheimer’s Dis Other Dementias®. 2020;35:153331751989672. doi: 10.1177/1533317519896725
  60. Cai M, Chen X, Shan J, Yang R, Guo Q, Bi X, Xu P, Shi X, Chu L, Wang L. Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID‑19 Rehabilitation. Front Pharmacol. 2021;12:643619. doi: 10.3389/fphar.2021.643619
  61. Arnaud C, Billoir E, de Melo Junior AF, Pereira SA, O’Halloran KD, Monteiro EC. Chronic intermittent hypoxia-induced cardiovascular and renal dysfunction: from adaptation to maladaptation. J Physiol. 2023;603(24). doi: 10.1113/JP284166
  62. Temme LA, Wittels HL, Wishon MJ, St. Onge P, McDonald SM, Hecocks D, Wittels SH. Continuous Physiological Monitoring of the Combined Exposure to Hypoxia and High Cognitive Load in Military Personnel. Biology (Basel). 2023;12(11):1398. doi: 10.3390/biology12111398
  63. Soo J, Girard O, Ihsan M, Fairchild T. The Use of the SpO2 to FiO2 Ratio to Individualize the Hypoxic Dose in Sport Science, Exercise, and Health Settings. Front Physiol. 2020;11:570472. doi: 10.3389/fphys.2020.570472
  64. Grushin AA, Zelenkova IE, Glazachev OS, Dudnik EN, Zotkin SV, Korneev PV, Koprov SV, Almyashev DH. Assessment of oxidative-antioxidant status and aerobic performance of elite cross-country skiers in the dynamics of training in the natural middle mountains. Sports medicine science and practice. 2019;9(4):11—20. (in Russian) doi: 10.17238/ISSN2223-2524.2019.4.11

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