The influence of genetic thrombogenic allelic polymorphisms to the first trimester of pregnancy course in pregnant women with chorion presentation

The associations of the most frequent carriages of allelic thrombogenic mutations and polymorphisms in women with chorion presentation in the first trimester of pregnancy living in the Altai region were determined in this research. 300 women were investigated and divided into three groups. It depends on the chorion presentation: the main group consisted of 50 patients with complete chorion presentation in the first trimester of pregnancy and the lack of migration in the second trimester; the comparison group included 150 pregnant women with chorion presentation in the first trimester and further migration in the second half of pregnancy; control group had 100 pregnant women with physiological placentation. The frequency of thrombogenic mutations and polymorphisms in women from the main group was in 82,0% of cases, whereas in the comparison group these genetic defects were revealed in 36,8% of cases and there were 3% in the control group. Intergenic associations were detected in 58% of cases, whereas in the comparison group in 7,3% of cases and they were absent in the control group. The condition of reproductive and somatic health of women with chorion presentation was also evaluated.

placenta presentation, placenta migration, reproductive health, extragenital diseases, thrombogenic genetic polymorphisms, folat metabolism, FV Leiden (R506Q G > A) mutation, prothrombin F2 (G20210 G > A), the inhibitor of plasminogen of the fist type activator PAI-I (675 4G/4G, 4G/5G)