Remodeling and diastolic dysfunction of the left ventricle in patients with arterial hypertension and polymorphism rs5918 of the ITGB3 gene: cross-sectional study
- Authors: Shambatov M.A.1, Izmozherova N.V.1,2, Popov A.A.1,2, Grishina I.F.1, Kudryavtseva E.V.1
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Affiliations:
- Ural State Medical University
- Institute of High Temperature Electrochemistry, Ural Branch of RAS
- Issue: Vol 14, No 2 (2023)
- Pages: 81-92
- Section: Original study articles
- URL: https://journals.rcsi.science/2221-7185/article/view/146650
- DOI: https://doi.org/10.17816/CS340870
- ID: 146650
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Abstract
OBJECTIVE: To identify diastolic myocardial function features in late postmenopausal women with polymorphic variants of the integrin beta-3 (ITGB3) gene and arterial hypertension.
MATERIALS AND METHODS: This cross-sectional study enrolled 97 postmenopausal women, with a median age of 67 (65÷70) years. The duration of menopause was 18 (16÷21) years. Molecular genetic studies to assess ITGB3 (rs5918) T1565C polymorphism were performed. The study participants with the homozygous TT ITGB3 polymorphic variant comprised group 1, whereas group 2 included patients with the C allele (TC and CC genotypes). All patients underwent standard transthoracic echocardiography and assessment of left ventricular (LV) diastolic function by transmitral flow. LV diastolic dysfunction was classified into rigid, pseudonormal, and restrictive.
RESULTS: Homozygous allelic variant TT was detected in 65 (67%) patients, heterozygous TC in 29 (30%), and homozygous polymorphic variant CC in 3 (3%). LVDD occurred in all patients included in the study. Among patients with the TT allelic variant of ITGB3, rigid LVDD was diagnosed in 34 (52%), and its pseudo-normal variant was detected in 31 (48%). Among TC and CC genotypes of C allele carriers, a pseudo-normal variant of LVDD (p <0.01), which occurred in 20 (62%) patients, was statistically significantly more frequently recorded, and 12 (38%) patients had a rigid type of LVDD. In addition, a rigid type LVDD was not detected in any case. Calcification of the mitral and aortic valve leaflets was detected in 24 (37%) cases in group 1 and in 9 (28%) patients in group 2 (p=0.68). In fibrous rings, calcifications were found in 34 (52%) patients in group 1 and 16 (50%) in group 2 (p=0.31), and the differences were not statistically significant.
CONCLUSION: This study presents a significant contribution of the rs5918 polymorphism of ITGB3 in the development of myocardial remodeling and LVDD in postmenopausal women.
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##article.viewOnOriginalSite##About the authors
Muraz A. Shambatov
Ural State Medical University
Author for correspondence.
Email: Muraz.shambatov@rambler.ru
ORCID iD: 0000-0001-7312-415X
SPIN-code: 6693-5347
Scopus Author ID: 57216921642
graduate student
Russian Federation, 3 Repina Str., 620028, EkaterinburgNadezhda V. Izmozherova
Ural State Medical University; Institute of High Temperature Electrochemistry, Ural Branch of RAS
Email: nadezhda_izm@mail.ru
ORCID iD: 0000-0001-7826-9657
SPIN-code: 4738-3269
Scopus Author ID: 19337559100
MD, Dr. Sci. (Med.), associate professor
Russian Federation, 3 Repina Str., 620028, Ekaterinburg; YekaterinburgArtem A. Popov
Ural State Medical University; Institute of High Temperature Electrochemistry, Ural Branch of RAS
Email: art_popov@mail.ru
ORCID iD: 0000-0001-6216-2468
SPIN-code: 5083-9389
Scopus Author ID: 24390984000
MD, Dr. Sci. (Med.), associate professor
Russian Federation, 3 Repina Str., 620028, Ekaterinburg; YekaterinburgIrina F. Grishina
Ural State Medical University
Email: grishif@mail.ru
ORCID iD: 0009-0005-8643-1825
SPIN-code: 5964-0857
Scopus Author ID: 7005557345
MD, Dr. Sci. (Med.), Professor
Russian Federation, 3 Repina Str., 620028, EkaterinburgElena V. Kudryavtseva
Ural State Medical University
Email: elenavladpopova@yandex.ru
ORCID iD: 0000-0003-2797-1926
SPIN-code: 7232-3743
Scopus Author ID: 57211989398
MD, Dr. Sci. (Med.), associate professor
Russian Federation, 3 Repina Str., 620028, EkaterinburgReferences
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