Predictors of microalbuminuria in workers of locomotive crews: prospective observational study

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Abstract

BACKGROUND: Cardiorenal relationships are one of the key problems in cardiology and nephrology. Microalbuminuria is a symptom of kidney pathologies and cardiovascular diseases. Studying the causes of microalbuminuria will help in solving the issue of pathological cardiorenal relationships.

AIM: To study the causes of the origin of microalbuminuria on the group of locomotive crews employees of the Trans-Baikal Railway.

MATERIALS AND METHODS: Predictors of microalbuminuria were established using data from a 6-year prospective follow-up of 22 clinical and anamnestic items in a natural cohort group of initially healthy 7,959 men (workers of locomotive crews) aged 18–66 years. A confusion matrix, multivariate regression model, and relative risk assessment were used for this purpose.

RESULTS: Microalbuminuria was found to be caused by excessive alcohol consumption, arterial hypertension, dyslipidemia, family history of early cardiovascular disease, grade I–II retinopathy, and smoking. The established predictors of microalbuminuria showed statistical heterogeneity in different analyses, referring to the significance of their assessment in the models used.

CONCLUSION: The statistical heterogeneity of microalbuminuria predictors of is probably determined by and related to their qualitative characteristics and the unique implementation of their damaging effect in the formation and progression of microalbuminuria at the cellular level. The results of the study showed the need to continue the examination of predictors of microalbuminuria using other statistical analysis tools until their unique specific characteristics are known and the effects of damage on the formation of this pathological symptom are clarified.

About the authors

Anna Yu. Lazutkina

Far Eastern Directorate of Healthcare – Structural Subdivision of the Central Directorate of Healthcare – Branch of Russian Railways

Author for correspondence.
Email: Lazutkina_AU59@mail.ru
ORCID iD: 0000-0003-3024-8632
SPIN-code: 3506-3471

MD, Cand. Sci. (Med.)

Russian Federation, Khabarovsk

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Supplementary files

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2. Fig. 1. Scheme of a prospective observational study of employees of locomotive crews of the Trans-Baikal Railway [10].

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3. Fig. 2. The influence of various environmental factors on the final outcome in the example of coronary heart disease [11].

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4. Fig. 3. The confounder interaction scheme [11].

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