Email this article Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
- Authors: Tregubov V.G.1, Khil′kevich P.V.1, Shubitidze I.Z.2, Tregubova A.V.1
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Affiliations:
- Kuban State Medical University
- Regional Clinical Hospital №2
- Issue: Vol 11, No 4 (2020)
- Pages: 25-29
- Section: Original study articles
- URL: https://journals.rcsi.science/2221-7185/article/view/60807
- DOI: https://doi.org/10.26442/22217185.2020.4.200565
- ID: 60807
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Abstract
Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF).
Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into two groups for treatment with bisoprolol or carvedilol. As part of the combination therapy was prescribed quinapril, and if indicated – atorvastatin, acetylsalicylic acid in the intestinal soluble shell. Initially and after 24 weeks of therapy were carried out: quantitative assessment of regulatory-adaptive status (RAS), echocardioscopy, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of level of N-terminal fragment of the brain natriuretic peptide precursor in blood plasma.
Results. Both schemes of combined therapy comparably improved the morpho-functional parameters of the heart and quality of life. In comparison with carvedilol, nebivolol more pronouncedly increased RAS and tolerance to physical activity.
Conclusion. In patients with diastolic CHF in combination therapy, the use of nebivolol, in comparison with carvedilol, may be preferable due to the positive effect on the functional state.
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##article.viewOnOriginalSite##About the authors
Vitalii G. Tregubov
Kuban State Medical University
Author for correspondence.
Email: vgtregubov@mail.ru
D. Sci. (Med.)
Russian Federation, KrasnodarPavel V. Khil′kevich
Kuban State Medical University
Email: vitiorus@mail.ru
Graduate Student
Russian Federation, KrasnodarIosif Z. Shubitidze
Regional Clinical Hospital №2
Email: iosif.shubitidze@mail.ru
cardiologist
Russian Federation, KrasnodarAnna V. Tregubova
Kuban State Medical University
Email: tregubova-anna@mail.ru
Student
Russian Federation, KrasnodarReferences
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