Interrelation of polymorphic allelic rs619203 option of a gene receptor of a tirozinkinaza (ROS1) with cardiovascular diseases at patients with an ischemic stroke

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Abstract

Studying of interrelation of polymorphic allelic rs619203 option of a gene of ROS1 with cardiovascular diseases at persons with the ischemic stroke is carried out. For the purpose of studying of a role of single nucleotide polymorphism of rs619203 of a gene of ROS1 in development of strokes of a genotiping 124 patients with ischemic stroke and cardiovascular pathology and 475 people of group of control. Persons with ischemic stroke are divided into subgroups according to a sex, the affected artery, the diseases which are available cardiovascular, risk factors, such as the raised body weight index, the burdened heredity on a stroke, smoking. For verification of the diagnosis by all patient standard neurologic examination, a computer tomography of a brain, and also the retrospective analysis of results of the previous inspections (are conducted at their existence), for definition of a genotype on ROS1 gene ONP - molecular and genetic research DNA. The received results showed prevalence of a homozygous genotype of GG on extended allel among patients from ischemic stroke having the arterial hypertension in comparison with control group. Thus, the genotype of GG has conditionally protective effect concerning development of ischemic stroke in persons with arterial hypertension.

About the authors

D. A Nikulin

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: nikulin86@list.ru
ассистент каф. неврологии с курсом реабилитации последипломного образования ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

V. A Shulman

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: ShulmanЗ6@mail.ru
д-р. мед. наук, проф. каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

S. V Prokopenko

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: Psv@mail.ru
д-р мед. наук, зав. каф. неврологии с курсом реабилитации последипломного образования ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

S. Yu Nikulina

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., проректор по учебной работе ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

A. A Chernova

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: anechkachernova@yandex.ru
д-р мед. наук, доц. каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

I. M Platunova

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: platunova_irina@mail.ru
аспирант каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно- Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

V. N Chernov

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: сhernovortstom@mail.ru
канд. мед. наук, доц. каф. ортопедической стоматологии ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

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