The functional significance of vasomotor arteries dysfunction in the clinical assessment of myocardial ischemia in case of carbohydrate metabolism disorder

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Abstract

We investigated the relationship between the severity of silent myocardial ischemia and the functional state of arteries endothelium. We studied the significance of violations of vasomotor function with the loss of the ability to flow-dependent vasodilation as a risk factor, which increases the probability of the episodes of silent myocardial ischemia among patients with Type II DM. We observed 128 patients (66 male and 62 female), average age was 59,3±4,7. Each patient signed an agreement to take part in our research as a volunteer. The agreement was adopted by the local ethics committee.Patients with coronary heart disease and Type II DM had dominating daily duration of episodes of myocardial ischemia and a maximum depth of ST segment depression. Besides, they had reduced endothelium-dependent vasodilation reaction (EDVD=3,7±1,1%). The violation of the functional state of the vascular endothelium correlates with the registration frequency (R=-0,68; p <0,05) and the duration of episodes of silent myocardial ischemia (R=-0,53; p <0,01).

About the authors

I. P Tatarchenko

Penza Extension Course Institute for Medical Practitioners

д-р мед. наук, проф., зав. каф. терапии, кардиологии и функциональной диагности- ки

N. V Pozdnyakova

Penza Extension Course Institute for Medical Practitioners; Federal State Health Institution, Medical Unit−59, Penza

Email: pozdnyakova-n-v@rambler.ru
д-р мед. наук, проф. каф. терапии, кардиологии и функциональной диагностики ГБОУ ДПО ПИУВ; гл. терапевт ФГБУЗ Медико-санитарная часть №5

A. G Mordovina

Penza Extension Course Institute for Medical Practitioners; Federal State Health Institution, Medical Unit−59, Penza

канд. мед. наук, доц. каф. терапии, кардиологии и функциональной диагностики ГБОУ ДПО ПИУВ; врач-эндокринолог ФГБУЗ Медико-санитарная часть №59

O. I Morozova

Penza Extension Course Institute for Medical Practitioners

д-р мед. наук, проф. каф. терапии, кардиологии и функциональной диагностики

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