Opportunities of ivabradine to reduce heart rate before CT coronary angiography in young patients with connective tissue dysplasia

To assess the efficacy and safety application ivabradine to control the heart rate before the procedure computed tomography coronary angiography (CTCA) in young patients with connective tissue dysplasia (CTD) were surveyed 65 patients (age 24,9±6,4 years; 40 men). Patients were divided into 2 groups: group 1 (n=47; 29 men) to achieve the heart rate <65 BPM ap-pointed ivabradine; group 2 (n=18; 11 men) was appointed bisoprolol. The effective average doses were as follows: group 1 - ivabradine 7,87±1,95 mg/day; group 2 - bisoprolol - 7,27±of 2,08 mg/day. Target heart rate, acceptable image quality were achieved by the absolute majority of patients in both groups. In group 2 has a distinct trend to reduction of blood pressure with severe subjective manifestations: 5 patients (8/18) complained of general weakness, headaches, episodes of dizziness; 4 patients (6/18) immediately after completion of the procedure MSCT marked ortostatical hypotension, which required the provision of medical assistance. In group 1 ortostatical hypotension after the procedure CTCA was also observed in 4 patients (4/47), which was significantly less than in group 2 (c2=4,40; p =0,0363). For the first time it is shown that the use of inhibitor of If-channels sinus node ivabradine for CTCA in this group of patients can effectively monitor the heart rate with the achievement of satisfactory quality CT image, has the following advantages over drugs group of b-blockers on tolerability and safety.

computed tomography, ivabradine, connective tissue dysplasia