The role of circulating autoantibodies in relation to proteins in structural cardiomyocytes and functional changes of the heart in patients with chronic myocarditis

Cover Page

Cite item

Full Text

Abstract

Evidence that has been progressively gathered implicates an important role of the immune system in the course of heart failure. In the majority of heart disease patients, disturbances of humoral immunity with production of cardiodepressant antibodies may play a functional role in cardiac dysfunction. This study evaluates the role of autoantibodies to the cardiac myosin. We examined 52 patients (from 14 till 61 years) with chronic myocarditis. The main examination methods were clinical and biochemical blood tests, ECG, ambulatory Holter ECG monitoring, echocardiography. Autoantibodies to the cardiac myosin were determined by ELISA. These autoantibodies correlate with myocardial inflammation. Also they are associated with structural changes of the heart (hypertrophy, dilation) and cardiac dysfunction (contractility, rhythm and conduction). The degree of expression of these disorders is related to the severity of chronic heart failure.

About the authors

E. V Gladysheva

S. M. KirovMilitary Medical Academy, Saint Petersburg

врач-кардиолог клиники военно-морской и госпитальной терапии

S. L Grishaev

S. M. KirovMilitary Medical Academy, Saint Petersburg

д-р мед. наук, доц., зам. нач. каф. военно-морской и госпитальной терапии

V. S Nikiforov

St. Petersburg State University

д-р мед. наук проф., проф. каф. функциональной диагностики ГБОУ ВПО СЗГМУ им. И.И.Мечникова

A. S Svistov

S. M. KirovMilitary Medical Academy, Saint Petersburg

д-р мед. наук, проф., нач. каф. военно-морской и госпитальной терапии

V. N Solntsev

St. Petersburg State University

ст. науч. сотр. математико-механического факультета ФГБОУ ВПО СПбГУ

References

  1. Горбаченков А.А., Поздняков Ю.М. Хронические болезни миокарда. М.: Синергия, 2005.
  2. Дерюгин М.В., Бойцов С.А. Хронические миокардиты. Спб.: ЭЛБИ-Спб., 2005.
  3. Палеев Н.Р., Палеев Ф.Н. Миокардиты. Иммунопатология миокардитов. Креативная кардиология. 2007; 1–2: 46–55.
  4. Luo H, Wong J, Wong B. Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. Cardiovasc Res 2010; 85 (2): 347–56.
  5. Caforio A.L.P, Mahon N.J, Tona F, Mc Kenna W.J. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. Eur J Heart Failure 2002; 4: 411–7.
  6. Mason J.W. Myocarditis and dilated cardiomyopathy: an inflammatory link. Cardiovasc Res 2003; 60 (1): 5–10.
  7. Warraich R.S, Noutsias M, Kazak I et al. Immunoglobulin G3 cardiac myosin autoantibodies correlate with left ventricular dysfunction in patients with dilated cardiomyopathy: immunoglobulin G3 and clinical correlates. Am Heart J 2002; 143 (6): 1076–84.
  8. Aso S, Yazaki Y, Kasai H et al. Anti - beta 1-adrenoreceptor autoantibodies and myocardial sympathetic nerve activity in chronic heart failure. Int J Cardiol 2009; 131 (2): 240–5.
  9. Jahns R, Boivin V, Krapf T et al. Direct evidence for a b1-adrenergic receptor - directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 2004; 113 (10): 1419–29.
  10. Wenzel K, Wallukat G, Qadri F et al. a1A-adrenergic receptor - directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats. PLoS One 2010; 5 (2): e9409; doi: 10.1371/journal.pone.0009409
  11. Радионуклидная диагностика для практических врачей. Под ред. Ю.Б.Лишманова, В.И.Чернова. Томск: SST, 2004. – С.99- 102.

Copyright (c) 2013 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies