The effect of a new coronavirus infection on hemogram parameters in the early convalescence period of patients with coronary heart disease
- Authors: Agarkov N.M.1,2, Yakunchenko T.I.2, Okhotnikov O.I.3, Makkonen K.F.2, Alymova M.V.1
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Affiliations:
- South-West State University
- Belgorod State National Research University
- Kursk State Medical University
- Issue: Vol 14, No 4 (2024)
- Pages: 740-746
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/2220-7619/article/view/268707
- DOI: https://doi.org/10.15789/2220-7619-TEO-17587
- ID: 268707
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Abstract
Laboratory data, especially a general blood test, play an important role in the treatment of infectious diseases, including COVID-19. However, in patients with coronary heart disease (CHD) and COVID-19, a general blood test is rarely analyzed and is insufficient to fully assess an impact of the new coronavirus infection on patients with cardiac diseases. The aim of the study was to analyze a COVID-19 effect on hemogram parameters in the early recovery period of patients with coronary heart disease. The study was performed at the Kursk City Clinical Hospital for Emergency Medical Care in the years 2021–2022, which involved 58 mature-aged patients (45–59 years old) suffering from coronary heart disease who had a new coronavirus infection and 62 elderly patients suffering from coronary heart disease alone. Morning blood sampling was carried out from the forearm superficial veins into Vacutainer test tubes added with a coagulation activator. In elderly patients, 3–4 weeks after recovery, significant changes in red blood parameters persisted — a decline in the level of peripheral blood erythrocytes, hemoglobin and hematocrit. Elderly patients with coronary heart disease comorbid with a moderate new coronavirus infection, 3–4 weeks later had also higher count of leukocytes, neutrophils, segmented neutrophils and ESR level relative to comparison group. It should be noted that in the early convalescence period elderly patients with coronary heart disease and COVID-19 had significantly elevated ESR, which confirms ongoing sustained inflammatory process. After evaluating the information content according to the calculated Kullback informativeness assessment for analyzed general blood test parameters, it was found to peak for platelet and leukocyte counts as well as ESR level. Thus, among the analyzed indicators in the general blood test, it turned out that platelet and leukocyte count along with ESR level were most informative and of prognostic significance during early convalescent period of elderly patients with coronary heart disease comorbid with a new coronavirus infection, which are proposed to be used as biomarkers of early convalescent period.
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##article.viewOnOriginalSite##About the authors
Nikolay M. Agarkov
South-West State University; Belgorod State National Research University
Author for correspondence.
Email: vitalaxen@mail.ru
DSc (Medicine), Professor, Professor of the Department of Biomedical Engineering; Senior Researcher, “Problems of Aging” Laboratory
Russian Federation, Kursk; BelgorodT. I. Yakunchenko
Belgorod State National Research University
Email: vitalaxen@mail.ru
DSc (Medicine), Professor, Head of the Department of Propaedeutics of Internal Diseases and Clinical Information Technologies
Russian Federation, BelgorodO. I. Okhotnikov
Kursk State Medical University
Email: vitalaxen@mail.ru
DSc (Medicine), Professor, Professor of the Department of Radiology and Radiotherapy
Russian Federation, KurskK. F. Makkonen
Belgorod State National Research University
Email: vitalaxen@mail.ru
DSc (Medicine), Associate Professor, Professor of the Department of Faculty Therapy
Russian Federation, BelgorodM. V. Alymova
South-West State University
Email: vitalaxen@mail.ru
Student, Department of Biomedical Engineering
Russian Federation, KurskReferences
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