Autoimmune disorders in patients with granulomatosis diseases after COVID-19: T- and B-cells subsets function

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Abstract

Sarcoidosis and tuberculosis are both granulomatous diseases that have many similarities, making the differential diagnosis of sarcoidosis and tuberculosis difficult, as well as leading to inappropriate treatment selection of both diseases. Autoimmune inflammation (AI) is one of the processes identified tuberculosis and sarcoidosis. Current evidences about the risk and clinical outcomes of COVID-19 infection in patient with sarcoidosis and M. tuberculosis co-infection are still not well understood. SARS-CoV-2 has direct damage to the epithelial cells of the respiratory system, and in-directly due to circulatory disorders. Materials and methods. In the study we analyzed characteristics of autoimmune response in patients with granulomatosis diseases (tuberculosis and sarcoidosis) after COVID-19. We have analyzed articles for the period of December 2019 to March 2023, published in international database (“Medline”, “PubMed”, “Scopus”). The keywords we used “COVID-19”, “SARS-CoV-2”, “tuberculosis”, “sarcoidosis”, “granulomatosis diseases”, “T cells”, “B cells”, “Treg”, “follicular Treg” and “Treg subsets”. The narrative review was carried out in accordance with the PRISMA protocol (http://www.prisma-statement.org) used for this type of study (ID-423604). Results. The influence of COVID-19 infection can also make a significant contribution to the violation of the T- and B-cell immune response, the violation of the nature of cellular metabolism, which will affect the course of granulomatous inflammation in various ways. According to the different researches, autoimmune inflammation can be an important protective mechanism in sarcoidosis and, at the same time, exacerbates the course of tuberculosis infection with the disease progression and pathogen drug resistance formation subsequently. The study of immune response features in patients with COVID-19 showed the presence of several similar characteristics in cellular components of the immune response. Conclusion. Evidence of the presence of autoimmune inflammation in patients with these granulomatous lung diseases, the development of patient immunotypes, including the transferred COVID-19, will be a significant contribution to the development of personalized patient management tactics, taking into account the identified violations of the immune response mechanisms.

About the authors

A. A. Starshinova

St. Petersburg State University; Almazov National Medical Research Centre

Email: arrubin6@mail.ru

DSc (Medicine), Head Researcher, Laboratory of Probabilistic Methods of Analysis, Mathematics Department; Head of the Research Department

Russian Federation, St. Petersburg; St. Petersburg

I. V. Kudryavtsev

Institution of Experimental Medicine

Email: arrubin6@mail.ru

PhD (Biology), Head of the Cell Immunology Laboratory, Department of Immunology

Russian Federation, St. Petersburg

A. A. Rubinstein

Institution of Experimental Medicine

Author for correspondence.
Email: arrubin6@mail.ru

Junior Researcher, Cell Immunology Laboratory, Department of Immunology

Russian Federation, St. Petersburg

A. Malkova

Ariel University

Email: arrubin6@mail.ru

PhD Student, Department of Molecular Biology, Faculty of Natural Sciences

Israel, Ariel

H. Ling

Harbin Medical University

Email: arrubin6@mail.ru

DSc (Medicine), Department of Microbiology, Immunology, Heilongjiang Provincial Key Laboratory of Infection and Immunity, Key Laboratory of Pathogen Biology

China, Harbin

M. Zhuang

Harbin Medical University

Email: arrubin6@mail.ru

DSc (Medicine), Department of Microbiology, Immunology, Heilongjiang Provincial Key Laboratory of Infection and Immunity, Key Laboratory of Pathogen Biology

China, Harbin

A. Yu. Starshinova

St. Petersburg State Pediatric Medical University

Email: arrubin6@mail.ru

Student of Medicine Department

Russian Federation, St. Petersburg

I. F. Dovgaluk

St. Petersburg Research Institute of Phthisiopulmonology

Email: arrubin6@mail.ru

DSc (Medicine), Professor, Leading Researcher, Head of Pediatric Tuberculosis Department

Russian Federation, St. Petersburg

D. A. Kudlay

I.M. Sechenov First Moscow State Medical University; Institute of Immunology FMBA of Russia

Email: arrubin6@mail.ru

DSc (Medicine), Professor of Pharmacology Department, Institute of Pharmacy; Leading Researcher, Laboratory of Personalized Medicine and Molecular Immunology

Russian Federation, Moscow; Moscow

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