A correlation between LP-PLA2 and monocyte levels in atherosclerosis risk subjects

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Abstract

Background. Cardiovascular disease (CVD) is the most significant cause of death worldwide. More than 17.9 million people died from CVD, of which 85% deceased due to heart disease. On the other hand, atherosclerosis is one of the most dominant CVD in most developing countries and developed countries. Lp-PLA2 is an enzyme produced by inflammatory cells and a pro-atherogenic protein in atherosclerosis. In the process, monocytes will produce Lp-PLA2 so that it may hydrolyse oxidized low density lipoprotein (oxLDL) into lysophosphatidylcholine (lysoPC) and oxidized fatty acids (oxFA), atherogenic proteins involved in atherogenesis. A chronic inflammatory process that occurs in atherosclerosis requires early detection to avoid CVD severity. The research aims to determine the correlation between Lp-PLA2 concentration and monocyte count as well as percentage in cohorts linked to risk of atherosclerosis. Materials and methods. This study was a descriptive correlational analysis of the population with conditions at risk of atherosclerosis. The total number of respondents sampled in this research was 86. We used the ELISA method to measure Lp-PLA2 concentration and the Hematology Analyzer method to measure monocyte count and percentage. Results. The relationship between monocyte and Lp-PLA2 level accounts for a probability value of 0.028. The correlation coefficient of 0.789 is categorized as very strong. Conclusion. Increase in the concentration of Lp-PLA2 correlates with monocyte count and percentage in a population with conditions at risk of atherosclerosis.

About the authors

K. Kumboyono

University of Brawijaya

Email: publikasikoe@gmail.com
ORCID iD: 0000-0003-2124-8673

School of Nursing, Faculty of Health Sciences

Indonesia, 65145, Malang

Indah N. Chomsy

University of Brawijaya

Email: indahncys@gmail.com
ORCID iD: 0000-0002-1050-3571

Doctoral Program of Medical Science, Faculty of Medicine

Indonesia, 65145, Malang

Dinesh Vijayadas

University of Brawijaya

Email: vidst@icloud.com

Medical Study Program, Faculty of Medicine

Indonesia, 65145, Malang

Titin A Wihastuti

University of Brawijaya

Author for correspondence.
Email: titinwihastuti@gmail.com
ORCID iD: 0000-0001-6476-0541

School of Nursing, Faculty of Health Sciences

Indonesia, 65145, Malang

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Copyright (c) 2022 Kumboyono K., Chomsy I.N., Vijayadas D., Wihastuti T.A.

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