Evolutionary aspects of gastrointestinal tract microbiome-host interaction underlying gastrointestinal barrier integrity

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Abstract

In the host sustenance and homeostasis, the microbiome is a key component in the functional system. Throughout ontogenetic development, microbiome including that of the gastrointestinal tract (GIT) is the vital factor that ensures not only host functioning, but also its interaction with environment. To uncover the mechanisms underlying GIT microbiome showing a decisive influence on host organism, a systematic approach is needed, because diverse microorganisms are predominantly localized in different parts of the GIT. Recently, a new interdisciplinary direction of science, nanobioinformatics that has been extensively developed considers “gene networks” as the major object of study representing a coordinated group of genes that functionally account for formation and phenotypic “disclosure” of various host traits. Here, an important place should be provided to the genetically determined level of the gastrointestinal tract microbiome, its interaction at the level of the host food systems. There have been increasing evidence indicating that the microbiome is directly involved in the pathogenesis of host diseases showing a multi-layered interaction with host metabolic and immune systems. At the same time, the microbial community is unevenly distributed throughout the gastrointestinal tract, and its different portions are variously active while interacting with the host immune system. The “architecture” of interaction between the microbiome and host cells is extremely complex, and the interaction of individual cells, at the same time, varies greatly. Bacteria colonizing the crypts of the small intestine regulate enterocyte proliferation by affecting DNA replication and gene expression, while bacteria at the tip of the intestinal villi mediate gene expression responsible for metabolism and immune response. Enterocytes and Paneth cells, in turn, regulate the vital activity of the community of microorganisms through the production of polysaccharides (carbohydrates) and antibacterial factors on their surface. Thus, the integrity of the gastrointestinal barrier (GIB) is maintained, which protects the body from infections and inflammation, while violation of its integrity leads to a number of diseases. It has been shown that depending on the dominance of certain types of bacteria the microbiome can maintain or disrupt GIB integrity. The structural and functional GIB integrity is important for body homeostasis. To date, at least 50 proteins have been characterized as being involved in the structural and functional integrability of tight junctions between gastrointestinal tract epithelial cells. The current review comprehensively discusses such issues and presents original research carried out at various facilities of translational biomedicine.

About the authors

S. I. Loskutov

All-Russian Research Institute for Food Additives — Branch of V.M. Gorbatov Federal Research Center for Food Systems of RAS

Author for correspondence.
Email: lislosk@mail.ru

PhD (Agriculture), Senior Researcher, Laboratory of Biotechnology and Bioengineering

 
Russian Federation, St. Petersburg

S. N. Proshin

Herzen University

Email: lislosk@mail.ru

PhD, MD (Medicine), Professor, Department of Medicine and Valeology

Russian Federation, St. Petersburg

D. S. Ryabukhin

All-Russian Research Institute for Food Additives — Branch of V.M. Gorbatov Federal Research Center for Food Systems of RAS

Email: lislosk@mail.ru

PhD (Chemistry), Senior Researcher

Russian Federation, St. Petersburg

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