POPULATION IMMUNITY TO INFLUENZA VIRUS A(H1N1)pdm09, A(H3N2) AND B IN THE ADULT POPULATION OF THE RUSSIAN FEDERATION LONG-TERM RESEARCH RESULTS
- Authors: Konshina O.S.1, Sominina A.A.1, Smorodintseva E.A.1, Stolyarov K.A.1, Nikonorov I.Y.1
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Affiliations:
- Research Institute of Influenza Ministry of Health of the Russian Federation
- Issue: Vol 7, No 1 (2017)
- Pages: 27-33
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/2220-7619/article/view/118511
- DOI: https://doi.org/10.15789/2220-7619-2017-1-27-33
- ID: 118511
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Abstract
Analysis of changes in the population immunity level in adults for more than 20 Russian cities, collaborating with the Federal Center for Influenza, to circulating influenza viruses A(H1N1)pdm09, A(H3N2) and B in the period from 2009 to 2015 performed. By the beginning of the pandemic (October 2009) the population of Russia was almost seronegative to influenza A(H1N1)pdm09 virus. After the pandemia first wave mean geometric titers (GMT)s of antibodies to the pandemic virus increased by 2.6 times, after the second one by 4.9 times in comparison with initial GMT (1:5.5). A consistent increase in GMTs antibody after each of the subsequent seasons of active circulation of pandemic virus was observed reaching the maximum (1:41) by April 2013, after the next epidemic caused by this virus. The proportion of people with protective antibody titers in October 2009 to already started circulating influenza A(H1N1)pdm09 virus was 8.2%, to influenza A(H3N2) virus — 58.3%, and influenza B virus — 59.7%. Level of population immunity in adults to seasonal influenza A(H3N2) and B viruses throughout the observed period was significantly higher than to influenza virus A(H1N1)pdm09. The percentage of persons with protective antibody titers during the observed period varied for virus A(H3N2) in the range from 58.3 to 75.5%, for influenza B virus — from 59.7 to 82.3%. Accordingly, incidence rate for ILI and ARI in adult groups the population during influenza epidemic caused by these pathogens was lower than in the epidemics, associated with active circulation of influenza A(H1N1)pdm09 virus. The data obtained can be used in influenza forecasting for the upcoming season regarding the etiology and the expected epidemic intensity need for the relevant preventing measures development to decrease the burden from influenza.
Keywords
About the authors
O. S. Konshina
Research Institute of Influenza Ministry of Health of the Russian Federation
Author for correspondence.
Email: olga.konshina@influenza.spb.ru
Researcher, Laboratory of Trials of Novel Remedies for Antiviral Protection
197376, Russian Federation, St. Petersburg, Prof. Popova str., 15/17, Phone: +7 921 920-18-11 (mobile)
Russian FederationA. A. Sominina
Research Institute of Influenza Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head of the Biotechnology Department, Head of the Laboratory of Biotechnology of Diagnostic Reagents
Russian FederationE. A. Smorodintseva
Research Institute of Influenza Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD (Medicine), Leading Researcher, Laboratory of Biotechnology of Diagnostic Reagents
Russian FederationK. A. Stolyarov
Research Institute of Influenza Ministry of Health of the Russian Federation
Email: fake@neicon.ru
Leading Software Developer, IT department Russian Federation
I. Yu. Nikonorov
Research Institute of Influenza Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD (Medicine), Leading Researcher, Laboratory of Trials of Novel Remedies for Antiviral Protection
Russian FederationReferences
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