Email this article Androgen deficiency in women with adrenal insufficiency. Dehydroepiandrosterone. Review
- Authors: Nuralieva NF1, Yukina MY.1, Troshina EA1, Platonova NM1
-
Affiliations:
- National Medical Research Center of Endocrinology of the Ministry of Health of Russian Federation
- Issue: Vol 20, No 4 (2018)
- Pages: 35-39
- Section: Articles
- URL: https://journals.rcsi.science/2079-5831/article/view/30087
- DOI: https://doi.org/10.26442/2079-5696_2018.4.35-39
- ID: 30087
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Abstract
It is known that adrenal insufficiency (AI) is a severe life-threatening disease due to the exceptional role of glucocorticoids and mineralocorticoids in the human body. At the same time, according to some reports, the deficit of androgens synthesized by the adrenal cortex (dehydroepiandrosterone - DHEA and dehydroepiandrosterone sulfate - DHEAS) is associated with an increased risk of death, including increased risk of adverse cardiovascular events, development of osteoporosis, diabetes mellitus and malignant neoplasms. The main source of DHEA and DHEAS in females are adrenal glands, so women with hypocorticism have significantly reduced (down to undetectable) levels of these hormones. However, due to lack of a reliable evidence and, accordingly, clinical recommendations, correction of androgen deficiency in patients with AI is usually not performed. The review discusses the accumulated data on the physiological significance of DHEA and DHEAS, their role in the development of various pathological conditions, as well as safety and efficacy of these drugs.
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##article.viewOnOriginalSite##About the authors
N F Nuralieva
National Medical Research Center of Endocrinology of the Ministry of Health of Russian Federation
Email: dr.nuralievanf@yandex.ru
науч. сотр. отд. терапевтической эндокринологии 117036, Russian Federation, Moscow, ul. Dmitry Ulyanov, d. 11
M Yu Yukina
National Medical Research Center of Endocrinology of the Ministry of Health of Russian Federation
Email: kuronova@yandex.ru
117036, Russian Federation, Moscow, ul. Dmitry Ulyanov, d. 11
E A Troshina
National Medical Research Center of Endocrinology of the Ministry of Health of Russian Federation
Email: troshina@inbox.ru
чл.-кор. РАН, д-р мед. наук, проф., зав. отд. терапевтической эндокринологии 117036, Russian Federation, Moscow, ul. Dmitry Ulyanov, d. 11
N M Platonova
National Medical Research Center of Endocrinology of the Ministry of Health of Russian Federation
Email: platonova@inbox.ru
д-р мед. наук, гл. науч. сотр. отд. терапевтической эндокринологии 117036, Russian Federation, Moscow, ul. Dmitry Ulyanov, d. 11
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