Asymmetrical labium majus enlargement (CALME) in childhood: A series of clinical cases
- 作者: Batyrova Z.K.1, Kymykova Z.K.1, Uvarova E.V.1,2, Badlaeva A.S.1, Asaturova A.V.1, Kulabukhova P.V.1, Mamedova F.S.1,3, Chuprynin V.D.1, Yagovkina I.A.1
-
隶属关系:
- Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
- Sechenov First Moscow State Medical University (Sechenov University)
- Russian Medical Academy of Continuous Professional Education
- 期: 卷 26, 编号 4 (2024)
- 页面: 363-367
- 栏目: CLINICAL CASE
- URL: https://journals.rcsi.science/2079-5831/article/view/277907
- DOI: https://doi.org/10.26442/20795696.2024.4.203036
- ID: 277907
如何引用文章
全文:
详细
Childhood asymmetry labium majus enlargement (CALME) is a rare, benign disease of pre-pubertal age characterized by non-neoplastic unilateral proliferation of the soft tissues of the vulva without a peripheral capsule. The pathogenesis of CALME is not completely clear. Generally, the only treatment method is surgery because it is necessary to verify the diagnosis and exclude the neoplastic process. Most studies indicate the benign nature of CALME and the importance of a non-surgical approach if specific diagnostic criteria are met. The article presents clinical observations of CALME syndrome in girls, taking into account the modern differentiated approach to the management of patients with this disorder.
作者简介
Zalina Batyrova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
编辑信件的主要联系方式.
Email: linadoctor@mail.ru
ORCID iD: 0000-0003-4997-6090
Cand. Sci. (Med.), Senior Res. Officer
俄罗斯联邦, MoscowZaira Kymykova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: linadoctor@mail.ru
ORCID iD: 0000-0001-7511-1432
Cand. Sci. (Med.)
俄罗斯联邦, MoscowElena Uvarova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology; Sechenov First Moscow State Medical University (Sechenov University)
Email: linadoctor@mail.ru
ORCID iD: 0000-0002-3105-5640
D. Sci. (Med.), Prof., Corr. Memb. RAS
俄罗斯联邦, Moscow; MoscowAlina Badlaeva
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: linadoctor@mail.ru
ORCID iD: 0000-0001-5223-9767
Res. Assist.
俄罗斯联邦, MoscowAleksandra Asaturova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: linadoctor@mail.ru
ORCID iD: 0000-0001-8739-5209
D. Sci. (Med.)
俄罗斯联邦, MoscowPolina Kulabukhova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: linadoctor@mail.ru
ORCID iD: 0000-0002-0363-3669
Cand. Sci. (Med.)
俄罗斯联邦, MoscowFatima Mamedova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology; Russian Medical Academy of Continuous Professional Education
Email: linadoctor@mail.ru
ORCID iD: 0000-0003-1136-7222
Cand. Sci. (Med.)
俄罗斯联邦, Moscow; MoscowVladimir Chuprynin
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: linadoctor@mail.ru
ORCID iD: 0000-0002-2997-9019
Cand. Sci. (Med.)
俄罗斯联邦, MoscowIrina Yagovkina
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: linadoctor@mail.ru
ORCID iD: 0009-0000-5121-9609
Medical Resident
俄罗斯联邦, Moscow参考
- Goldrat O, Lingier P, Massez A, Noël JC. Prepubertal Vulvar Fibroma: Neoplasm or Physiological Condition? J Pediatr Adolesc Gynecol. 2016;29(5):e67-70. doi: 10.1016/j.jpag.2016.02.003
- Батырова З.К., Уварова Е.В., Кумыкова З.Х. CALME, или доброкачественная асимметрия большой половой губы, в детском возрасте. В помощь практикующему врачу. Репродуктивное здоровье детей и подростков. 2024;20(1):52-6 [Batyrova ZK, Uvarova EV, Kumykova ZKh. CALME, or benign asymmetry of the labia majora in childhood. To help a practicing doctor. Pediatric and Adolescent Reproductive Health. 2024;20(1):52-6 (in Russian)]. doi: 10.33029/1816-2134-2024-20-1-52-56
- Vargas SO, Kozakewich HP, Boyd TK, et al. Childhood asymmetric labium majus enlargement: Mimicking a neoplasm. Am J Surg Pathol. 2005;29:1007-16. PMID: 16006794
- Lowry DL, Guido RS. The vulvar mass in the prepubertal child. J Pediatr Adolesc Gynecol. 2000;13(2):75-8. doi: 10.1016/s1083-3188(00)00007-3
- Altchek A, Deligdisch L, Norton K, et al. Prepubertal unilateral fibrous hyperplasia of the labium majus: Report of eight cases and review of the literature. Obstet Gynecol. 2007;110(1):103-8. doi: 10.1097/01.AOG.0000266979.42237.cc
- Salvatori C, Testa I, Prestipino M, et al. Childhood Asymmetry Labium Majus Enlargement (CALME): Description of Two Cases. Int J Environ Res Public Health. 2018;15(7):1525. doi: 10.3390/ijerph15071525
- Gu MJ, Kim SY. Childhood asymmetry labium majus enlargement. Korean J Pathol. 2011;45:529.
- Sechi A, Patrizi A, Vara G, et al. Keep CALME (childhood asymmetry labium majus enlargement) and follow up. J Dtsch Dermatol Ges. 2021;19(9):1276-81. doi: 10.1111/ddg.14528
- Iwasa Y, Fletcher CD. Distinctive prepubertal vulval fibroma: A hitherto unrecognized mesenchymal tumor of prepubertal girls: Analysis of 11 cases. Am J Surg Pathol. 2004;28(12):1601-8. doi: 10.1097/00000478-200412000-00008
- Oh JT, Choi SH, Ahn SG, et al. Vulvar lipomas in children: An analysis of 7 cases. J Pediatr Surg. 2009;44(10):1920-3. doi: 10.1016/j.jpedsurg.2009.02.063
- Manson CM, Hirsch PJ, Coyne JD. Postoperative spindle cell nodule of the vulva. Histopathology. 1995;26(6):571-4. doi: 10.1111/j.1365-2559.1995.tb00277.x
- Soyer T, Hançerliogullari O, Pelin Cil A, et al. Childhood asymmetric labium majus enlargement: is a conservative approach available? J Pediatr Adolesc Gynecol. 2009;22(2):e9–11.
补充文件
