Aging-Associated Changes in the Reproductive Function of Drosophila melanogaster Offspring


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Аннотация

A comparative analysis of parental age-associated changes in the reproductive function and embryonic development has been performed for offspring of D. melanogaster imagoes of mutant (wCS1 and wOr1) and wild-type (Canton-S and Oregon-R) lines. Fruit fly imagoes from three age groups (3-, 10-, and 20-day-old) were used in the experiment. Reciprocal crossings of young (3-day-old) imagoes to individuals from each age group were performed in order to identify the effects of maternal and/or paternal age on reproductive function parameters in the offspring. The effects of maternal and paternal ages on various reproductive function parameters in F1 offspring were shown to vary between wild-type lines and mutant lines wCS1 and wOr1 which is apparently due to genetic differences between the lines. The white mutation alone or combined with advanced parental age had a negative effect on fertility and viability characteristics in F1 offspring and caused a predisposition to the development of dominant lethal mutations and death at the pupal stage, such that the emergence of less adapted and viable offspring in the population was prevented.

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Авторлар туралы

V. Kostenko

Institute of Fundamental Medicine and Biology

Хат алмасуға жауапты Автор.
Email: vvkostenko1@gmail.com
Ресей, Kazan, 420008

N. Kolot

Karazin National University

Email: vvkostenko1@gmail.com
Украина, Kharkiv, 61022

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